Version history

{
  "scope": "mouse V1 L2/3 paired patch",
  "claim_text": "In mouse V1 L2/3, paired-recording analysis confirms VIP cells exhibit an adapting firing pattern (during depolarizing current injection) in direct contrast to the fast-spiking pattern of PV interneurons — a fundamental intrinsic-physiology difference that, combined with their opposite synaptic dynamics onto Martinotti cells (PV→MC depression vs VIP→MC facilitation), establishes class-specific temporal niches for cortical disinhibition.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/ncomms13664",
    "claim": "In mouse V1 L2/3, paired-recording analysis confirms VIP cells exhibit an adapting firing pattern (during depolarizing current injection) in direct contrast to the fast-spiking pattern of PV interneurons — a fundamental intrinsic-physiology difference that, combined with their opposite synaptic dynamics onto Martinotti cells (PV→MC depression vs VIP→MC facilitation), establishes class-specific temporal niches for cortical disinhibition.",
    "title": null,
    "cite_key": "Walker2016",
    "evidence": "paired patch in mouse V1 L2/3 (Karnani 2016 NatComm)",
    "effect_size": "PV→MC connection probability ~90%, VIP→MC ~80%; PV fast spiking; VIP adapting",
    "text_access": "fulltext",
    "study_system": "mouse V1 L2/3 paired patch",
    "_source_cluster": "cluster_04_intrinsic_electrophysiology",
    "replication_status": "replicated",
    "_source_cluster_index": 81,
    "claim_source_sentence": "During depolarizing current injections, the PV cell shows a fast spiking pattern, whereas the VIP cell shows an adapting firing pattern.",
    "replication_evidence_dois": [
      "10.1093/cercor/bhv202",
      "10.1038/nn.4216"
    ],
    "effect_size_source_sentence": "Single presynaptic spikes reliably (PV to MC: ~90%; VIP to MC: ~80%) elicited unitary IPSCs in MC."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "effect_size": "PV→MC connection probability ~90%, VIP→MC ~80%; PV fast spiking; VIP adapting",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-e93955349823"
  ],
  "source_span": "During depolarizing current injections, the PV cell shows a fast spiking pattern, whereas the VIP cell shows an adapting firing pattern.",
  "study_system": "mouse V1 L2/3 paired patch",
  "evidence_refs": [
    {
      "ref": "paper:paper-e93955349823"
    }
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "paired patch in mouse V1 L2/3 (Karnani 2016 NatComm)",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}