Details
- scope
- mouse V1 L2/3 paired patch
- section_id
- section_05
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json
- effect_size
- PV→MC connection probability ~90%, VIP→MC ~80%; PV fast spiking; VIP adapting
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-05-electrophysiology
- source_kind
- review_finding
- source_path
- evidence/section_05_evidence_package.json
- source_span
- During depolarizing current injections, the PV cell shows a fast spiking pattern, whereas the VIP cell shows an adapting firing pattern.
- study_system
- mouse V1 L2/3 paired patch
- section_title
- Intrinsic Electrophysiology
- evidence_summary
- paired patch in mouse V1 L2/3 (Karnani 2016 NatComm)
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- replicated
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-05-electrophysiology
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- claim_text
In mouse V1 L2/3, paired-recording analysis confirms VIP cells exhibit an adapting firing pattern (during depolarizing current injection) in direct contrast to the fast-spiking pattern of PV interneurons — a fundamental intrinsic-physiology difference that, combined with their opposite synaptic dynamics onto Martinotti cells (PV→MC depression vs VIP→MC facilitation), establishes class-specific temporal niches for cortical disinhibition.
- raw_fields
{ "n": null, "doi": "10.1038/ncomms13664", "claim": "In mouse V1 L2/3, paired-recording analysis confirms VIP cells exhibit an adapting firing pattern (during depolarizing current injection) in direct contrast to the fast-spiking pattern of PV interneurons — a fundamental intrinsic-physiology difference that, combined with their opposite synaptic dynamics onto Martinotti cells (PV→MC depression vs VIP→MC facilitation), establishes class-specific temporal niches for cortical disinhibition.", "title": null, "cite_key": "Walker2016", "evidence": "paired patch in mouse V1 L2/3 (Karnani 2016 NatComm)", "effect_size": "PV→MC connection probability ~90%, VIP→MC ~80%; PV fast spiking; VIP adapting", "text_access": "fulltext", "study_system": "mouse V1 L2/3 paired patch", "_source_cluster": "cluster_04_intrinsic_electrophysiology", "replication_status": "replicated", "_source_cluster_index": 81, "claim_source_sentence": "During depolarizing current injections, the PV cell shows a fast spiking pattern, whereas the VIP cell shows an adapting firing pattern.", "replication_evidence_dois": [ "10.1093/cercor/bhv202", "10.1038/nn.4216" ], "effect_size_source_sentence": "Single presynaptic spikes reliably (PV to MC: ~90%; VIP to MC: ~80%) elicited unitary IPSCs in MC." }- source_refs
[ "paper:paper-e93955349823" ]
- evidence_refs
[ { "ref": "paper:paper-e93955349823" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }