Version history

{
  "scope": "mouse V1, LM, PM visual cortex, sCRACM in acute slices",
  "claim_text": "In the L2/3 feedforward pathway from V1 to PM, excitatory input to PV interneurons was on average 12.85-fold stronger than to neighboring pyramidal neurons, whereas in the feedback pathway from PM to V1, PV excitation was only 1.93-fold stronger, revealing a gradual scaling of inhibition/excitation balance from the most feedforward to the most feedback pathway.",
  "raw_fields": {
    "n": 14,
    "doi": "10.7554/elife.19332",
    "claim": "In the L2/3 feedforward pathway from V1 to PM, excitatory input to PV interneurons was on average 12.85-fold stronger than to neighboring pyramidal neurons, whereas in the feedback pathway from PM to V1, PV excitation was only 1.93-fold stronger, revealing a gradual scaling of inhibition/excitation balance from the most feedforward to the most feedback pathway.",
    "cite_key": "DSouza2016",
    "evidence": "Subcellular ChR2-assisted circuit mapping (sCRACM) was used in acute slices to measure excitatory postsynaptic currents in neighboring PV and pyramidal neuron pairs in L2/3 across feedforward and feedback pathways interconnecting V1, LM, and PM.",
    "effect_size": "FF(V1→PM) PV/Pyr EPSC ratio = 12.85 ± 4.48 (n=14 pairs, p<0.001); FB(PM→V1) PV/Pyr EPSC ratio = 1.93 ± 0.44 (n=21 pairs); FF vs FB difference p<0.001",
    "text_access": "fulltext",
    "study_system": "mouse V1, LM, PM visual cortex, sCRACM in acute slices",
    "argument_role": "supporting",
    "replication_status": "consistent_with_prior",
    "claim_source_sentence": "In the L2/3 FFpathway, EPSCs recorded from PV cells were larger than those from Pyr cells ().",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "The mean total current in PV cells was 12.85 ± 4.48-fold stronger than that in neighboring Pyr cells (p<0.001, n = 14 pairs)."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "effect_size": "FF(V1→PM) PV/Pyr EPSC ratio = 12.85 ± 4.48 (n=14 pairs, p<0.001); FB(PM→V1) PV/Pyr EPSC ratio = 1.93 ± 0.44 (n=21 pairs); FF vs FB difference p<0.001",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-c0b096c22b35"
  ],
  "source_span": "In the L2/3 FFpathway, EPSCs recorded from PV cells were larger than those from Pyr cells ().",
  "study_system": "mouse V1, LM, PM visual cortex, sCRACM in acute slices",
  "evidence_refs": [
    {
      "ref": "paper:paper-c0b096c22b35"
    }
  ],
  "section_title": "5. Horizontal long-range intracortical excitatory connections in mouse — patchy L2/3-L5 axons, similarity tuning, distance-decay",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Subcellular ChR2-assisted circuit mapping (sCRACM) was used in acute slices to measure excitatory postsynaptic currents in neighboring PV and pyramidal neuron pairs in L2/3 across feedforward and feedback pathways interconnecting V1, LM, and PM.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "consistent_with_prior",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}