In the L2/3 feedforward pathway from V1 to PM, excitatory input to PV interneur…

In the L2/3 feedforward pathway from V1 to PM, excitatory input to PV interneurons was on average 12.85-fold stronger than to neighboring pyramidal neurons, whereas in the feedback pathway from PM to V1, PV excitation was only 1.93-fold stronger, revealing a gradual scaling of inhibition/excitation balance from the most feedforward to the most feedback pathway.

{
  "n": 14,
  "doi": "10.7554/elife.19332",
  "claim": "In the L2/3 feedforward pathway from V1 to PM, excitatory input to PV interneurons was on average 12.85-fold stronger than to neighboring pyramidal neurons, whereas in the feedback pathway from PM to V1, PV excitation was only 1.93-fold stronger, revealing a gradual scaling of inhibition/excitation balance from the most feedforward to the most feedback pathway.",
  "cite_key": "DSouza2016",
  "evidence": "Subcellular ChR2-assisted circuit mapping (sCRACM) was used in acute slices to measure excitatory postsynaptic currents in neighboring PV and pyramidal neuron pairs in L2/3 across feedforward and feedback pathways interconnecting V1, LM, and PM.",
  "effect_size": "FF(V1→PM) PV/Pyr EPSC ratio = 12.85 ± 4.48 (n=14 pairs, p<0.001); FB(PM→V1) PV/Pyr EPSC ratio = 1.93 ± 0.44 (n=21 pairs); FF vs FB difference p<0.001",
  "text_access": "fulltext",
  "study_system": "mouse V1, LM, PM visual cortex, sCRACM in acute slices",
  "argument_role": "supporting",
  "replication_status": "consistent_with_prior",
  "claim_source_sentence": "In the L2/3 FFpathway, EPSCs recorded from PV cells were larger than those from Pyr cells ().",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "The mean total current in PV cells was 12.85 ± 4.48-fold stronger than that in neighboring Pyr cells (p<0.001, n = 14 pairs)."
}

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Subcellular ChR2-assisted circuit mapping (sCRACM) was used in acute slices to measure excitatory postsynaptic currents in neighboring PV and pyramidal neuron pairs in L2/3 across feedforward and feedback pathways interconnecting V1, LM, and PM.