Version history

{
  "scope": "rat hippocampus CA1 (3, 6–7, 12 weeks)",
  "claim_text": "VPAC1-receptor modulation of hippocampal LTP changes with postweaning development: PG 97-269 antagonist effect on TBS-induced LTP is much larger in juvenile (3-week-old) than in young adult (6–7-week-old) or adult (12-week-old) rats, despite no developmental change in synaptic VPAC1 receptor density. Synaptic VIP and VPAC1 levels rise progressively during postweaning development.",
  "raw_fields": {
    "n": null,
    "doi": "10.3390/biom14030379",
    "claim": "VPAC1-receptor modulation of hippocampal LTP changes with postweaning development: PG 97-269 antagonist effect on TBS-induced LTP is much larger in juvenile (3-week-old) than in young adult (6–7-week-old) or adult (12-week-old) rats, despite no developmental change in synaptic VPAC1 receptor density. Synaptic VIP and VPAC1 levels rise progressively during postweaning development.",
    "title": null,
    "cite_key": "Gil2024",
    "evidence": "TBS-induced LTP in CA1 hippocampal slices from rats at 3, 6–7, and 12 weeks; Western blot of total + synaptosomal VIP, VPAC1, VPAC2, VGAT, gephyrin, VGlut1, PSD-95.",
    "effect_size": null,
    "figure_data": null,
    "text_access": "fulltext",
    "key_entities": [
      "VPAC1",
      "VPAC2",
      "VIP",
      "postweaning",
      "juvenile",
      "LTP",
      "GABAergic",
      "hippocampus",
      "critical period",
      "TBS"
    ],
    "study_system": "rat hippocampus CA1 (3, 6–7, 12 weeks)",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "single_study",
    "_source_cluster_index": 135,
    "claim_source_sentence": "The influence of the VPAC1 receptor antagonist PG 97-269 (100 nM) on TBS-induced LTP was much larger in juvenile (3-week-old) than in young adult (6–7-week-old) or adult (12-week-old) rats. This effect was not associated with a developmental decrease in synaptic VPAC1 receptor levels. ... in hippocampal synaptosomes, both VIP and to a lesser extent VPAC1 receptors increased along post-weaning development by 58.3 ± 15.9% and 43.7 ± 10.1% (n = 5, p < 0.05).",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-775c87964210"
  ],
  "source_span": "The influence of the VPAC1 receptor antagonist PG 97-269 (100 nM) on TBS-induced LTP was much larger in juvenile (3-week-old) than in young adult (6–7-week-old) or adult (12-week-old) rats. This effect was not associated with a developmental decrease in synaptic VPAC1 receptor levels. ... in hippocampal synaptosomes, both VIP and to a lesser extent VPAC1 receptors increased along post-weaning development by 58.3 ± 1...",
  "study_system": "rat hippocampus CA1 (3, 6–7, 12 weeks)",
  "evidence_refs": [
    {
      "ref": "paper:paper-775c87964210"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "TBS-induced LTP in CA1 hippocampal slices from rats at 3, 6–7, and 12 weeks; Western blot of total + synaptosomal VIP, VPAC1, VPAC2, VGAT, gephyrin, VGlut1, PSD-95.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}