VPAC1-receptor modulation of hippocampal LTP changes with postweaning developme…

VPAC1-receptor modulation of hippocampal LTP changes with postweaning development: PG 97-269 antagonist effect on TBS-induced LTP is much larger in juvenile (3-week-old) than in young adult (6–7-week-old) or adult (12-week-old) rats, despite no developmental change in synaptic VPAC1 receptor density. Synaptic VIP and VPAC1 levels rise progressively during postweaning development.

{
  "n": null,
  "doi": "10.3390/biom14030379",
  "claim": "VPAC1-receptor modulation of hippocampal LTP changes with postweaning development: PG 97-269 antagonist effect on TBS-induced LTP is much larger in juvenile (3-week-old) than in young adult (6–7-week-old) or adult (12-week-old) rats, despite no developmental change in synaptic VPAC1 receptor density. Synaptic VIP and VPAC1 levels rise progressively during postweaning development.",
  "title": null,
  "cite_key": "Gil2024",
  "evidence": "TBS-induced LTP in CA1 hippocampal slices from rats at 3, 6–7, and 12 weeks; Western blot of total + synaptosomal VIP, VPAC1, VPAC2, VGAT, gephyrin, VGlut1, PSD-95.",
  "effect_size": null,
  "figure_data": null,
  "text_access": "fulltext",
  "key_entities": [
    "VPAC1",
    "VPAC2",
    "VIP",
    "postweaning",
    "juvenile",
    "LTP",
    "GABAergic",
    "hippocampus",
    "critical period",
    "TBS"
  ],
  "study_system": "rat hippocampus CA1 (3, 6–7, 12 weeks)",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "single_study",
  "_source_cluster_index": 135,
  "claim_source_sentence": "The influence of the VPAC1 receptor antagonist PG 97-269 (100 nM) on TBS-induced LTP was much larger in juvenile (3-week-old) than in young adult (6–7-week-old) or adult (12-week-old) rats. This effect was not associated with a developmental decrease in synaptic VPAC1 receptor levels. ... in hippocampal synaptosomes, both VIP and to a lesser extent VPAC1 receptors increased along post-weaning development by 58.3 ± 15.9% and 43.7 ± 10.1% (n = 5, p < 0.05).",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:paper-775c87964210"
]

The influence of the VPAC1 receptor antagonist PG 97-269 (100 nM) on TBS-induced LTP was much larger in juvenile (3-week-old) than in young adult (6–7-week-old) or adult (12-week-old) rats. This effect was not associated with a developmental decrease in synaptic VPAC1 receptor levels. ... in hippocampal synaptosomes, both VIP and to a lesser extent VPAC1 receptors increased along post-weaning development by 58.3 ± 1...

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    "ref": "paper:paper-775c87964210"
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  "notes": [
    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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