Version history

{
  "scope": "mouse somatosensory cortex L5; paired patch-clamp",
  "claim_text": "L5 SST interneurons receive intralaminar inhibition from both PV and VIP cells with cell-type-specific short-term plasticity (PV→SST depressing; VIP→SST facilitating at high frequency), and translaminar input from L2/3 VIP—but not L2/3 PV—cells, reproducing the disinhibitory motif previously characterized in supragranular layers.",
  "raw_fields": {
    "n": null,
    "doi": "10.1113/jp288309",
    "claim": "L5 SST interneurons receive intralaminar inhibition from both PV and VIP cells with cell-type-specific short-term plasticity (PV→SST depressing; VIP→SST facilitating at high frequency), and translaminar input from L2/3 VIP—but not L2/3 PV—cells, reproducing the disinhibitory motif previously characterized in supragranular layers.",
    "title": null,
    "cite_key": "Preuss2026",
    "evidence": "Triple transgenic mice; paired whole-cell patch-clamp recordings in acute somatosensory cortex slices; intra- and translaminar connection rates and short-term plasticity assessed.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse somatosensory cortex L5; paired patch-clamp",
    "target_section": "section_05",
    "_source_cluster": "cluster_01_molecular_taxonomy",
    "replication_status": "replication_unknown",
    "_source_cluster_index": 88,
    "claim_source_sentence": "PV to SST connections were depressing at all tested frequencies, whereas VIP to SST connections were facilitating at high-frequency VIP IN stimulation. In addition translaminar inputs from L2/3 VIP to L5 SST IN showed similar connectivity rates and short-term plasticity compared to their L5 counterparts. However L2/3 PV IN, despite numerous descending axon collaterals, showed hardly any connection.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-11-disease-translational",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-737e539c1091"
  ],
  "source_span": "PV to SST connections were depressing at all tested frequencies, whereas VIP to SST connections were facilitating at high-frequency VIP IN stimulation. In addition translaminar inputs from L2/3 VIP to L5 SST IN showed similar connectivity rates and short-term plasticity compared to their L5 counterparts. However L2/3 PV IN, despite numerous descending axon collaterals, showed hardly any connection.",
  "study_system": "mouse somatosensory cortex L5; paired patch-clamp",
  "evidence_refs": [
    {
      "ref": "paper:paper-737e539c1091"
    }
  ],
  "section_title": "Species Differences, Human Relevance, and Disease",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Triple transgenic mice; paired whole-cell patch-clamp recordings in acute somatosensory cortex slices; intra- and translaminar connection rates and short-term plasticity assessed.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-11-disease-translational",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}