- claim_text
L5 SST interneurons receive intralaminar inhibition from both PV and VIP cells with cell-type-specific short-term plasticity (PV→SST depressing; VIP→SST facilitating at high frequency), and translaminar input from L2/3 VIP—but not L2/3 PV—cells, reproducing the disinhibitory motif previously characterized in supragranular layers.
- raw_fields
{
"n": null,
"doi": "10.1113/jp288309",
"claim": "L5 SST interneurons receive intralaminar inhibition from both PV and VIP cells with cell-type-specific short-term plasticity (PV→SST depressing; VIP→SST facilitating at high frequency), and translaminar input from L2/3 VIP—but not L2/3 PV—cells, reproducing the disinhibitory motif previously characterized in supragranular layers.",
"title": null,
"cite_key": "Preuss2026",
"evidence": "Triple transgenic mice; paired whole-cell patch-clamp recordings in acute somatosensory cortex slices; intra- and translaminar connection rates and short-term plasticity assessed.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse somatosensory cortex L5; paired patch-clamp",
"target_section": "section_05",
"_source_cluster": "cluster_01_molecular_taxonomy",
"replication_status": "replication_unknown",
"_source_cluster_index": 88,
"claim_source_sentence": "PV to SST connections were depressing at all tested frequencies, whereas VIP to SST connections were facilitating at high-frequency VIP IN stimulation. In addition translaminar inputs from L2/3 VIP to L5 SST IN showed similar connectivity rates and short-term plasticity compared to their L5 counterparts. However L2/3 PV IN, despite numerous descending axon collaterals, showed hardly any connection.",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-737e539c1091"
]
- source_span
PV to SST connections were depressing at all tested frequencies, whereas VIP to SST connections were facilitating at high-frequency VIP IN stimulation. In addition translaminar inputs from L2/3 VIP to L5 SST IN showed similar connectivity rates and short-term plasticity compared to their L5 counterparts. However L2/3 PV IN, despite numerous descending axon collaterals, showed hardly any connection.
- evidence_refs
[
{
"ref": "paper:paper-737e539c1091"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}