Version history

{
  "scope": "Mouse vibrissal S1 L2/3, awake behaving; two-photon imaging + photoablation + computational model",
  "claim_text": "In mouse vibrissal somatosensory cortex L2/3 during active tactile discrimination, recurrent E→E coupling within feature-specific subnetworks amplifies sensory responses: photoablating only 10–20 'touch'-tuned neurons (<5% of population) markedly reduces touch responses in the spared population — direct causal evidence of selective recurrent amplification.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/s41586-020-2062-x",
    "claim": "In mouse vibrissal somatosensory cortex L2/3 during active tactile discrimination, recurrent E→E coupling within feature-specific subnetworks amplifies sensory responses: photoablating only 10–20 'touch'-tuned neurons (<5% of population) markedly reduces touch responses in the spared population — direct causal evidence of selective recurrent amplification.",
    "cite_key": "Peron2020",
    "evidence": "Two-photon imaging of mouse vS1 L2/3 during whisker-based tactile discrimination combined with cell-specific photoablation of small subsets of 'touch'-selective neurons; data-constrained network model.",
    "effect_size": "ablation of 10–20 touch neurons (<5% of population) markedly reduced touch responses in the spared touch representation, but not in other representations",
    "text_access": "abstract_only",
    "study_system": "Mouse vibrissal S1 L2/3, awake behaving; two-photon imaging + photoablation + computational model",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Recurrence among cortical neurons with similar selectivity therefore drives input-specific amplification during behaviour.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1038/s41586-019-0997-6"
    ],
    "effect_size_source_sentence": "Ablation of a small proportion of layer 2/3 neurons (10-20, less than 5% of the total) representing touch markedly reduced responses in the spared touch representation, but not in other representations."
  },
  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "effect_size": "ablation of 10–20 touch neurons (<5% of population) markedly reduced touch responses in the spared touch representation, but not in other representations",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "source_kind": "review_finding",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:0ea946e4-6a52-4cca-8dff-399434ffcf2a"
  ],
  "source_span": "Recurrence among cortical neurons with similar selectivity therefore drives input-specific amplification during behaviour.",
  "study_system": "Mouse vibrissal S1 L2/3, awake behaving; two-photon imaging + photoablation + computational model",
  "evidence_refs": [
    {
      "ref": "paper:0ea946e4-6a52-4cca-8dff-399434ffcf2a"
    }
  ],
  "section_title": "9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Two-photon imaging of mouse vS1 L2/3 during whisker-based tactile discrimination combined with cell-specific photoablation of small subsets of 'touch'-selective neurons; data-constrained network model.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}