In mouse vibrissal somatosensory cortex L2/3 during active tactile discriminati…

In mouse vibrissal somatosensory cortex L2/3 during active tactile discrimination, recurrent E→E coupling within feature-specific subnetworks amplifies sensory responses: photoablating only 10–20 'touch'-tuned neurons (<5% of population) markedly reduces touch responses in the spared population — direct causal evidence of selective recurrent amplification.

{
  "n": 0,
  "doi": "10.1038/s41586-020-2062-x",
  "claim": "In mouse vibrissal somatosensory cortex L2/3 during active tactile discrimination, recurrent E→E coupling within feature-specific subnetworks amplifies sensory responses: photoablating only 10–20 'touch'-tuned neurons (<5% of population) markedly reduces touch responses in the spared population — direct causal evidence of selective recurrent amplification.",
  "cite_key": "Peron2020",
  "evidence": "Two-photon imaging of mouse vS1 L2/3 during whisker-based tactile discrimination combined with cell-specific photoablation of small subsets of 'touch'-selective neurons; data-constrained network model.",
  "effect_size": "ablation of 10–20 touch neurons (<5% of population) markedly reduced touch responses in the spared touch representation, but not in other representations",
  "text_access": "abstract_only",
  "study_system": "Mouse vibrissal S1 L2/3, awake behaving; two-photon imaging + photoablation + computational model",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Recurrence among cortical neurons with similar selectivity therefore drives input-specific amplification during behaviour.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1038/s41586-019-0997-6"
  ],
  "effect_size_source_sentence": "Ablation of a small proportion of layer 2/3 neurons (10-20, less than 5% of the total) representing touch markedly reduced responses in the spared touch representation, but not in other representations."
}

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    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
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