Version history

{
  "scope": "adult mouse primary motor cortex",
  "claim_text": "Patch-seq of >1,300 adult mouse primary motor cortex neurons morpho-electrically annotated nearly all transcriptomic types, finding broad transcriptomic families (Vip, Pvalb, Sst, etc.) had non-overlapping morpho-electric phenotypes while individual transcriptomic types within a family were not well separated in morpho-electric space.",
  "raw_fields": {
    "n": 1300,
    "doi": "10.1038/s41586-020-2907-3",
    "claim": "Patch-seq of >1,300 adult mouse primary motor cortex neurons morpho-electrically annotated nearly all transcriptomic types, finding broad transcriptomic families (Vip, Pvalb, Sst, etc.) had non-overlapping morpho-electric phenotypes while individual transcriptomic types within a family were not well separated in morpho-electric space.",
    "cite_key": "Scala2021",
    "evidence": "Patch-seq combining whole-cell patch-clamp, biocytin filling, and full-transcriptome single-cell sequencing of >1,300 cortical neurons in adult mouse M1.",
    "effect_size": "1,300+ neurons; broad transcriptomic families separable in morpho-electric space but fine within-family types overlap",
    "text_access": "abstract_only",
    "study_system": "adult mouse primary motor cortex",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Here we used Patch-seqto combine patch-clamp recording, biocytin staining, and single-cell RNA sequencing of more than 1,300 neurons in adult mouse primary motor cortex, providing a morpho-electric annotation of almost all transcriptomically defined neural cell types.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1101/2023.11.25.568393",
      "10.1038/s41586-021-03950-0"
    ],
    "effect_size_source_sentence": "…although broad families of transcriptomic types (those expressing Vip, Pvalb, Sst and so on) had distinct and essentially non-overlapping morpho-electric phenotypes, individual transcriptomic types within the same family were not well separated in the morpho-electric space."
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "effect_size": "1,300+ neurons; broad transcriptomic families separable in morpho-electric space but fine within-family types overlap",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-be132b319290"
  ],
  "source_span": "Here we used Patch-seqto combine patch-clamp recording, biocytin staining, and single-cell RNA sequencing of more than 1,300 neurons in adult mouse primary motor cortex, providing a morpho-electric annotation of almost all transcriptomically defined neural cell types.",
  "study_system": "adult mouse primary motor cortex",
  "evidence_refs": [
    {
      "ref": "paper:paper-be132b319290"
    }
  ],
  "section_title": "7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Patch-seq combining whole-cell patch-clamp, biocytin filling, and full-transcriptome single-cell sequencing of >1,300 cortical neurons in adult mouse M1.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}