- raw_fields
{
"n": 0,
"doi": "10.1038/nature11466",
"claim": "Midbrain dopaminergic neurons release GABA via VMAT2-dependent vesicular packaging that rapidly inhibits both direct- and indirect-pathway SPNs, complicating dopamine's classical opposing-pathway action.",
"cite_key": "Tritsch2012",
"evidence": "",
"effect_size": "DA neuron activation rapidly inhibits both D1 and D2 SPN firing via vesicular GABA release",
"text_access": "abstract_only",
"study_system": "mouse striatal slice, optogenetic activation of dopaminergic axons, electrophysiology",
"source_cluster_id": "cluster_04",
"replication_status": "replication_unknown",
"claim_source_sentence": "Here we show that activation of dopamine neurons in striatal slices rapidly inhibits action potential firing in both direct- and indirect-pathway striatal projection neurons through vesicular release of the inhibitory transmitter GABA (γ-aminobutyric acid).",
"replication_evidence_dois": [],
"effect_size_source_sentence": "Here we show that activation of dopamine neurons in striatal slices rapidly inhibits action potential firing in both direct- and indirect-pathway striatal projection neurons through vesicular release of the inhibitory transmitter GABA (γ-aminobutyric acid)."
}- source_refs
[
"paper:paper-039206b94a5f"
]
- source_span
Here we show that activation of dopamine neurons in striatal slices rapidly inhibits action potential firing in both direct- and indirect-pathway striatal projection neurons through vesicular release of the inhibitory transmitter GABA (γ-aminobutyric acid).
- evidence_refs
[
{
"ref": "paper:paper-039206b94a5f"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}