Version history

{
  "scope": "mouse striatal slice, optogenetic activation of dopaminergic axons, electrophysiology",
  "claim_text": "Midbrain dopaminergic neurons release GABA via VMAT2-dependent vesicular packaging that rapidly inhibits both direct- and indirect-pathway SPNs, complicating dopamine's classical opposing-pathway action.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/nature11466",
    "claim": "Midbrain dopaminergic neurons release GABA via VMAT2-dependent vesicular packaging that rapidly inhibits both direct- and indirect-pathway SPNs, complicating dopamine's classical opposing-pathway action.",
    "cite_key": "Tritsch2012",
    "evidence": "",
    "effect_size": "DA neuron activation rapidly inhibits both D1 and D2 SPN firing via vesicular GABA release",
    "text_access": "abstract_only",
    "study_system": "mouse striatal slice, optogenetic activation of dopaminergic axons, electrophysiology",
    "source_cluster_id": "cluster_04",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "Here we show that activation of dopamine neurons in striatal slices rapidly inhibits action potential firing in both direct- and indirect-pathway striatal projection neurons through vesicular release of the inhibitory transmitter GABA (γ-aminobutyric acid).",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Here we show that activation of dopamine neurons in striatal slices rapidly inhibits action potential firing in both direct- and indirect-pathway striatal projection neurons through vesicular release of the inhibitory transmitter GABA (γ-aminobutyric acid)."
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json",
  "effect_size": "DA neuron activation rapidly inhibits both D1 and D2 SPN firing via vesicular GABA release",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-04",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-039206b94a5f"
  ],
  "source_span": "Here we show that activation of dopamine neurons in striatal slices rapidly inhibits action potential firing in both direct- and indirect-pathway striatal projection neurons through vesicular release of the inhibitory transmitter GABA (γ-aminobutyric acid).",
  "study_system": "mouse striatal slice, optogenetic activation of dopaminergic axons, electrophysiology",
  "evidence_refs": [
    {
      "ref": "paper:paper-039206b94a5f"
    }
  ],
  "section_title": "Striatal Output Pathways: Direct, Indirect, and Beyond",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-04",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}