Version history

{
  "scope": "mouse vHPC, CCK-Cre intersectional",
  "claim_text": "Intersectional CCK-targeted optogenetic and chemogenetic manipulation of ventral hippocampal CCK interneurons gates the vHPC-NAc projection that supports contextual reward memory.",
  "raw_fields": {
    "n": 8,
    "doi": "10.1016/j.isci.2024.108824",
    "claim": "Intersectional CCK-targeted optogenetic and chemogenetic manipulation of ventral hippocampal CCK interneurons gates the vHPC-NAc projection that supports contextual reward memory.",
    "cite_key": "Nguyen2024",
    "evidence": "Transsynaptic rabies tracing + intersectional CCK genetic targeting + ex vivo and in vivo optogenetics.",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "mouse vHPC, CCK-Cre intersectional",
    "source_cluster_id": "cluster_10",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "Here, we demonstrate that the encoding of context-reward memory requires a ventral hippocampus (vHPC) to nucleus accumbens (NAc) circuit that is gated by cholecystokinin (CCK) interneurons.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-11",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-f4e2a843941e"
  ],
  "source_span": "Here, we demonstrate that the encoding of context-reward memory requires a ventral hippocampus (vHPC) to nucleus accumbens (NAc) circuit that is gated by cholecystokinin (CCK) interneurons.",
  "study_system": "mouse vHPC, CCK-Cre intersectional",
  "evidence_refs": [
    {
      "ref": "paper:paper-f4e2a843941e"
    }
  ],
  "section_title": "Cell-Type-Specific Dissection of Loop Circuits (Opto/Chemo/Tracing)",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Transsynaptic rabies tracing + intersectional CCK genetic targeting + ex vivo and in vivo optogenetics.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-11",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}