Details
- scope
- mouse vHPC, CCK-Cre intersectional
- claim_text
- Intersectional CCK-targeted optogenetic and chemogenetic manipulation of ventral hippocampal CCK interneurons gates the vHPC-NAc projection that supports contextual reward memory.
- section_id
- section_11
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-11
- source_kind
- review_finding
- source_path
- evidence/section_11_evidence_package.json
- source_span
- Here, we demonstrate that the encoding of context-reward memory requires a ventral hippocampus (vHPC) to nucleus accumbens (NAc) circuit that is gated by cholecystokinin (CCK) interneurons.
- study_system
- mouse vHPC, CCK-Cre intersectional
- section_title
- Cell-Type-Specific Dissection of Loop Circuits (Opto/Chemo/Tracing)
- evidence_summary
- Transsynaptic rabies tracing + intersectional CCK genetic targeting + ex vivo and in vivo optogenetics.
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-11
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (4)
- raw_fields
{ "n": 8, "doi": "10.1016/j.isci.2024.108824", "claim": "Intersectional CCK-targeted optogenetic and chemogenetic manipulation of ventral hippocampal CCK interneurons gates the vHPC-NAc projection that supports contextual reward memory.", "cite_key": "Nguyen2024", "evidence": "Transsynaptic rabies tracing + intersectional CCK genetic targeting + ex vivo and in vivo optogenetics.", "effect_size": null, "text_access": "fulltext", "study_system": "mouse vHPC, CCK-Cre intersectional", "source_cluster_id": "cluster_10", "replication_status": "replication_unknown", "claim_source_sentence": "Here, we demonstrate that the encoding of context-reward memory requires a ventral hippocampus (vHPC) to nucleus accumbens (NAc) circuit that is gated by cholecystokinin (CCK) interneurons.", "replication_evidence_dois": [], "effect_size_source_sentence": null }- source_refs
[ "paper:paper-f4e2a843941e" ]
- evidence_refs
[ { "ref": "paper:paper-f4e2a843941e" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }