Version history

{
  "scope": "mouse (slice patch-clamp + glutamate uncaging in DLS)",
  "claim_text": "Sub-cellular glutamate uncaging mapping of barrel-cortex inputs onto individual SPNs in mouse dorsolateral striatum revealed that each SPN was innervated by neurons in only a small number of whisker columns scattered across the barrel field, with neighbouring SPNs sharing few common cortical clusters, despite a population-level topographic projection.",
  "raw_fields": {
    "n": null,
    "doi": "10.7554/elife.106621",
    "claim": "Sub-cellular glutamate uncaging mapping of barrel-cortex inputs onto individual SPNs in mouse dorsolateral striatum revealed that each SPN was innervated by neurons in only a small number of whisker columns scattered across the barrel field, with neighbouring SPNs sharing few common cortical clusters, despite a population-level topographic projection.",
    "cite_key": "Amroune2025",
    "evidence": "Ex vivo patch-clamp recordings in dorsolateral striatum combined with focal glutamate uncaging across the barrel cortex; comparison of D1- and D2-SPN innervation patterns.",
    "effect_size": "single-SPN innervation: small number of discontinuous whisker columns; D1 and D2 SPNs receive similar patterns but differ in synaptic strength from associative L2/3",
    "text_access": "fulltext",
    "study_system": "mouse (slice patch-clamp + glutamate uncaging in DLS)",
    "source_cluster_id": "cluster_03",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "Finally, SPNs were innervated by cells distributed in close to 3 columns (2.7±0.2), though some SPNs with several clusters (54%) were innervated by as many as eight columns (Figure 3D).",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Finally, we found similar innervation patterns for D1- and D2-type SPNs, but observed differences in synaptic strength in their connections with certain cortical layers, notably the associative layer 2/3."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_03_evidence_package.json",
  "effect_size": "single-SPN innervation: small number of discontinuous whisker columns; D1 and D2 SPNs receive similar patterns but differ in synaptic strength from associative L2/3",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-03",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-f092a34fa3c2"
  ],
  "source_span": "Finally, SPNs were innervated by cells distributed in close to 3 columns (2.7±0.2), though some SPNs with several clusters (54%) were innervated by as many as eight columns (Figure 3D).",
  "study_system": "mouse (slice patch-clamp + glutamate uncaging in DLS)",
  "evidence_refs": [
    {
      "ref": "paper:paper-f092a34fa3c2"
    }
  ],
  "section_title": "The Cortico-Striatal Interface: Topography, Cell Types, and Input Convergence",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Ex vivo patch-clamp recordings in dorsolateral striatum combined with focal glutamate uncaging across the barrel cortex; comparison of D1- and D2-SPN innervation patterns.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-03",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_03_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}