Sub-cellular glutamate uncaging mapping of barrel-cortex inputs onto individual…

Sub-cellular glutamate uncaging mapping of barrel-cortex inputs onto individual SPNs in mouse dorsolateral striatum revealed that each SPN was innervated by neurons in only a small number of whisker columns scattered across the barrel field, with neighbouring SPNs sharing few common cortical clusters, despite a population-level topographic projection.

{
  "n": null,
  "doi": "10.7554/elife.106621",
  "claim": "Sub-cellular glutamate uncaging mapping of barrel-cortex inputs onto individual SPNs in mouse dorsolateral striatum revealed that each SPN was innervated by neurons in only a small number of whisker columns scattered across the barrel field, with neighbouring SPNs sharing few common cortical clusters, despite a population-level topographic projection.",
  "cite_key": "Amroune2025",
  "evidence": "Ex vivo patch-clamp recordings in dorsolateral striatum combined with focal glutamate uncaging across the barrel cortex; comparison of D1- and D2-SPN innervation patterns.",
  "effect_size": "single-SPN innervation: small number of discontinuous whisker columns; D1 and D2 SPNs receive similar patterns but differ in synaptic strength from associative L2/3",
  "text_access": "fulltext",
  "study_system": "mouse (slice patch-clamp + glutamate uncaging in DLS)",
  "source_cluster_id": "cluster_03",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Finally, SPNs were innervated by cells distributed in close to 3 columns (2.7±0.2), though some SPNs with several clusters (54%) were innervated by as many as eight columns (Figure 3D).",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Finally, we found similar innervation patterns for D1- and D2-type SPNs, but observed differences in synaptic strength in their connections with certain cortical layers, notably the associative layer 2/3."
}

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]

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