- claim_text
Synergistic deficits in parvalbumin interneurons and dopamine signaling drive ACC dysfunction in chronic pain — Chronic pain arises from maladaptive changes in both peripheral and central nervous systems, including the anterior cingulate cortex (ACC), a key region implica
- raw_fields
{
"n": 0,
"doi": "10.1073/pnas.2502558122",
"claim": "Synergistic deficits in parvalbumin interneurons and dopamine signaling drive ACC dysfunction in chronic pain — Chronic pain arises from maladaptive changes in both peripheral and central nervous systems, including the anterior cingulate cortex (ACC), a key region implica",
"title": null,
"cite_key": "Lancon2025",
"evidence": "Reported in Proceedings of the National Academy of Sciences of the United States of America (2025); from Body of abstract.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse",
"_source_cluster": "cluster_05_synaptic_connectivity",
"replication_status": "replication_unknown",
"_source_cluster_index": 388,
"claim_source_sentence": "Chronic pain arises from maladaptive changes in both peripheral and central nervous systems, including the anterior cingulate cortex (ACC), a key region implicated in descending pain modulation.",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-0acff15589a5"
]
- evidence_refs
[
{
"ref": "paper:paper-0acff15589a5"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}