Version history

{
  "scope": "vip-interneurons",
  "claim_text": "Distinct neuromodulatory pathways (basal forebrain ACh, locus coeruleus NE) recruit highly specific cortical VIP/NOS/CCK interneuron subtypes that mediate region- and state-dependent neurovascular coupling, providing a mechanistic basis by which neuromodulator state alters BOLD signals.",
  "raw_fields": {
    "n": null,
    "doi": "10.1098/rstb.2015.0350",
    "year": "2016",
    "claim": "Distinct neuromodulatory pathways (basal forebrain ACh, locus coeruleus NE) recruit highly specific cortical VIP/NOS/CCK interneuron subtypes that mediate region- and state-dependent neurovascular coupling, providing a mechanistic basis by which neuromodulator state alters BOLD signals.",
    "title": "Neuronal networks and mediators of cortical neurovascular coupling responses in normal and altered brain states",
    "journal": "",
    "species": "multiple",
    "cite_key": "Lecrux2016",
    "evidence": "Review integrating slice and in vivo work on cortical interneuron + neuromodulatory pathway circuits.",
    "effect_size": "VIP/NOS+ interneurons mediated cholinergic-evoked vasodilation; SST cells gave NPY/SST-mediated vasoconstriction.",
    "text_access": "fulltext",
    "_source_cluster": "cluster_13_neuromodulation",
    "replication_status": "single_study",
    "_source_cluster_index": 32,
    "claim_source_sentence": "The neural circuits recruited by whisker glutamatergic-, basal forebrain cholinergic- or locus coeruleus noradrenergic pathway stimulation were found to be highly specific and discriminative.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Using the whisker-to-barrel pathway as a model of NVC, we can interrogate the reliability of NVC under enhanced cholinergic or noradrenergic modulation of cortical circuits."
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "effect_size": "VIP/NOS+ interneurons mediated cholinergic-evoked vasodilation; SST cells gave NPY/SST-mediated vasoconstriction.",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-fe3c0e54ee6e"
  ],
  "source_span": "The neural circuits recruited by whisker glutamatergic-, basal forebrain cholinergic- or locus coeruleus noradrenergic pathway stimulation were found to be highly specific and discriminative.",
  "study_system": null,
  "evidence_refs": [
    {
      "ref": "paper:paper-fe3c0e54ee6e"
    }
  ],
  "section_title": "Oscillatory Dynamics and Temporal Coordination",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Review integrating slice and in vivo work on cortical interneuron + neuromodulatory pathway circuits.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}