Version history

{
  "scope": "Acute slices of P5–P16 mouse sensorimotor cortex; LSPS plus whole-cell patch-clamp on layer 5 pyramidal neurons",
  "claim_text": "In mouse sensorimotor cortex, an NMDA-receptor-only input from layer 2/3 to layer 5 pyramidal cells is present transiently during early postnatal development (around P5–P12) and is converted to AMPA-receptor-mediated input by ~P16, marking the maturation of the canonical L2/3→L5 translaminar pathway.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.1262-12.2012",
    "claim": "In mouse sensorimotor cortex, an NMDA-receptor-only input from layer 2/3 to layer 5 pyramidal cells is present transiently during early postnatal development (around P5–P12) and is converted to AMPA-receptor-mediated input by ~P16, marking the maturation of the canonical L2/3→L5 translaminar pathway.",
    "cite_key": "Anastasiades2012",
    "evidence": "Laser scanning photostimulation of caged glutamate plus whole-cell patch-clamp at -70 and +40 mV to separately map AMPA- and NMDA-receptor inputs onto developing L5 pyramidal cells in mouse sensorimotor cortex.",
    "effect_size": "L2/3→L5 NMDAR-only inputs: transient peak P5–P12 → AMPAR-converted by P16.",
    "text_access": "abstract_only",
    "study_system": "Acute slices of P5–P16 mouse sensorimotor cortex; LSPS plus whole-cell patch-clamp on layer 5 pyramidal neurons",
    "argument_role": "supporting",
    "replication_status": "single_study",
    "claim_source_sentence": "This revealed distal MK-801-sensitive synaptic inputs that predict the formation of the mature, canonical layer 2/3 to 5 pathway. However, these were a transient feature and had been almost entirely converted to AMPAR synapses at a later age (P16).",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Over the subsequent week this coalesced and shifted, primarily influenced by an increased contribution from layers 2/3 cells, which became a prominent motif of the afferent input onto layer 5 pyramidal cells regardless of cortical region."
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "L2/3→L5 NMDAR-only inputs: transient peak P5–P12 → AMPAR-converted by P16.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-1affbf67307f"
  ],
  "source_span": "This revealed distal MK-801-sensitive synaptic inputs that predict the formation of the mature, canonical layer 2/3 to 5 pathway. However, these were a transient feature and had been almost entirely converted to AMPAR synapses at a later age (P16).",
  "study_system": "Acute slices of P5–P16 mouse sensorimotor cortex; LSPS plus whole-cell patch-clamp on layer 5 pyramidal neurons",
  "evidence_refs": [
    {
      "ref": "paper:paper-1affbf67307f"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Laser scanning photostimulation of caged glutamate plus whole-cell patch-clamp at -70 and +40 mV to separately map AMPA- and NMDA-receptor inputs onto developing L5 pyramidal cells in mouse sensorimotor cortex.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}