In mouse sensorimotor cortex, an NMDA-receptor-only input from layer 2/3 to lay…

In mouse sensorimotor cortex, an NMDA-receptor-only input from layer 2/3 to layer 5 pyramidal cells is present transiently during early postnatal development (around P5–P12) and is converted to AMPA-receptor-mediated input by ~P16, marking the maturation of the canonical L2/3→L5 translaminar pathway.

{
  "n": 0,
  "doi": "10.1523/jneurosci.1262-12.2012",
  "claim": "In mouse sensorimotor cortex, an NMDA-receptor-only input from layer 2/3 to layer 5 pyramidal cells is present transiently during early postnatal development (around P5–P12) and is converted to AMPA-receptor-mediated input by ~P16, marking the maturation of the canonical L2/3→L5 translaminar pathway.",
  "cite_key": "Anastasiades2012",
  "evidence": "Laser scanning photostimulation of caged glutamate plus whole-cell patch-clamp at -70 and +40 mV to separately map AMPA- and NMDA-receptor inputs onto developing L5 pyramidal cells in mouse sensorimotor cortex.",
  "effect_size": "L2/3→L5 NMDAR-only inputs: transient peak P5–P12 → AMPAR-converted by P16.",
  "text_access": "abstract_only",
  "study_system": "Acute slices of P5–P16 mouse sensorimotor cortex; LSPS plus whole-cell patch-clamp on layer 5 pyramidal neurons",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "This revealed distal MK-801-sensitive synaptic inputs that predict the formation of the mature, canonical layer 2/3 to 5 pathway. However, these were a transient feature and had been almost entirely converted to AMPAR synapses at a later age (P16).",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Over the subsequent week this coalesced and shifted, primarily influenced by an increased contribution from layers 2/3 cells, which became a prominent motif of the afferent input onto layer 5 pyramidal cells regardless of cortical region."
}

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  "paper:paper-1affbf67307f"
]

This revealed distal MK-801-sensitive synaptic inputs that predict the formation of the mature, canonical layer 2/3 to 5 pathway. However, these were a transient feature and had been almost entirely converted to AMPAR synapses at a later age (P16).

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