Version history

{
  "scope": "Mouse cortex in vivo, opsin-free controls",
  "claim_text": "Optical-fiber laser stimulation at 637, 594 or 473 nm in mouse cortex without exogenous opsins evoked strong contralateral visual-cortex neuronal responses even at low intensities (1 mW at fiber tip), most pronounced at 637 nm — a methodological caveat for optogenetic-stimulation studies in mouse cortex.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.isci.2024.111152",
    "claim": "Optical-fiber laser stimulation at 637, 594 or 473 nm in mouse cortex without exogenous opsins evoked strong contralateral visual-cortex neuronal responses even at low intensities (1 mW at fiber tip), most pronounced at 637 nm — a methodological caveat for optogenetic-stimulation studies in mouse cortex.",
    "cite_key": "Weiler2024",
    "evidence": "Opsin-free control mice; cross-wavelength dose response; dim background-light rescue suppresses off-target activation at 594/473 nm but not at higher 637-nm intensities.",
    "effect_size": "responses at 1 mW fiber tip power; ≤2.5 mW required to suppress 637-nm-evoked off-target activation under dim light",
    "text_access": "fulltext",
    "study_system": "Mouse cortex in vivo, opsin-free controls",
    "argument_role": "supporting",
    "replication_status": "single-study-methodological-caveat",
    "claim_source_sentence": "Here, we found that optical fiber laser stimulation at wavelengths of 637, 594, or 473 nm within the cortex of mice lacking expression of exogenous opsins resulted in a strong neuronal response in the contralateral visual cortex. Evoked responses were observed even at low laser intensities (fiber tip power 1 mW) and most pronounced at 637 nm.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Evoked responses were observed even at low laser intensities (fiber tip power 1 mW) and most pronounced at 637 nm."
  },
  "section_id": "section_15",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_15_evidence_package.json",
  "effect_size": "responses at 1 mW fiber tip power; ≤2.5 mW required to suppress 637-nm-evoked off-target activation under dim light",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-15-methods-limits",
  "source_kind": "review_finding",
  "source_path": "evidence/section_15_evidence_package.json",
  "source_refs": [
    "paper:paper-5515978cc90a"
  ],
  "source_span": "Here, we found that optical fiber laser stimulation at wavelengths of 637, 594, or 473 nm within the cortex of mice lacking expression of exogenous opsins resulted in a strong neuronal response in the contralateral visual cortex. Evoked responses were observed even at low laser intensities (fiber tip power 1 mW) and most pronounced at 637 nm.",
  "study_system": "Mouse cortex in vivo, opsin-free controls",
  "evidence_refs": [
    {
      "ref": "paper:paper-5515978cc90a"
    }
  ],
  "section_title": "15. Methodological limits and emerging tools — what current mouse-cortex tools cannot yet measure about E→E recurrence (subthreshold network activity, fast plasticity in vivo, millimetre-scale dynamic connectomes), and what is on the near horizon",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Opsin-free control mice; cross-wavelength dose response; dim background-light rescue suppresses off-target activation at 594/473 nm but not at higher 637-nm intensities.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single-study-methodological-caveat",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-15-methods-limits",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_15_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}