Version history

{
  "scope": "computational model of dorsal striatum with support from striatal recordings (species not specified)",
  "claim_text": "Simultaneous activation of functionally opponent direct- and indirect-pathway spiny projection neurons following action selection resolves a fundamental inconsistency between striatal reinforcement learning models and known SPN synaptic plasticity rules.",
  "raw_fields": {
    "n": null,
    "doi": "10.7554/elife.101747",
    "claim": "Simultaneous activation of functionally opponent direct- and indirect-pathway spiny projection neurons following action selection resolves a fundamental inconsistency between striatal reinforcement learning models and known SPN synaptic plasticity rules.",
    "cite_key": "Lindsey2025",
    "evidence": "Computational modeling of striatal reinforcement learning combined with analysis of striatal recording data to test predictions about concurrent dSPN and iSPN activation during action selection.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "computational model of dorsal striatum with support from striatal recordings (species not specified)",
    "source_cluster_id": "cluster_01",
    "replication_status": "novel",
    "claim_source_sentence": "However, this pathological behavior is reversed if functionally opponent dSPNs and iSPNs, which promote and suppress the current behavior, are simultaneously activated by efferent input following action selection.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_01",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_01_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-01",
  "source_kind": "review_finding",
  "source_path": "evidence/section_01_evidence_package.json",
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    "paper:paper-64428af7e294"
  ],
  "source_span": "However, this pathological behavior is reversed if functionally opponent dSPNs and iSPNs, which promote and suppress the current behavior, are simultaneously activated by efferent input following action selection.",
  "study_system": "computational model of dorsal striatum with support from striatal recordings (species not specified)",
  "evidence_refs": [
    {
      "ref": "paper:paper-64428af7e294"
    }
  ],
  "section_title": "Introduction: Swanson's Loop Hypothesis and Its Intellectual Lineage",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
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  "evidence_summary": "Computational modeling of striatal reinforcement learning combined with analysis of striatal recording data to test predictions about concurrent dSPN and iSPN activation during action selection.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "novel",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-01",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_01_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}