- claim_text
Simultaneous activation of functionally opponent direct- and indirect-pathway spiny projection neurons following action selection resolves a fundamental inconsistency between striatal reinforcement learning models and known SPN synaptic plasticity rules.
- raw_fields
{
"n": null,
"doi": "10.7554/elife.101747",
"claim": "Simultaneous activation of functionally opponent direct- and indirect-pathway spiny projection neurons following action selection resolves a fundamental inconsistency between striatal reinforcement learning models and known SPN synaptic plasticity rules.",
"cite_key": "Lindsey2025",
"evidence": "Computational modeling of striatal reinforcement learning combined with analysis of striatal recording data to test predictions about concurrent dSPN and iSPN activation during action selection.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "computational model of dorsal striatum with support from striatal recordings (species not specified)",
"source_cluster_id": "cluster_01",
"replication_status": "novel",
"claim_source_sentence": "However, this pathological behavior is reversed if functionally opponent dSPNs and iSPNs, which promote and suppress the current behavior, are simultaneously activated by efferent input following action selection.",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-64428af7e294"
]
- evidence_refs
[
{
"ref": "paper:paper-64428af7e294"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}