Version history

{
  "scope": "Mouse V1 (visual cortex); electron microscopy; two-photon imaging; layer L2/3; pyramidal cells",
  "claim_text": "Combined two-photon calcium imaging and EM reconstruction of mouse V1 L2/3 found preferential excitatory connectivity between pyramidal cells with similar orientation preferences operates at the spine scale (~1–5 μm).",
  "raw_fields": {
    "n": 1278,
    "doi": "10.1038/nature17192",
    "claim": "Combined two-photon calcium imaging and EM reconstruction of mouse V1 L2/3 found preferential excitatory connectivity between pyramidal cells with similar orientation preferences operates at the spine scale (~1–5 μm).",
    "cite_key": "Lee2016",
    "evidence": "Permutation and Cochran–Armitage tests on EM-reconstructed L2/3 excitatory connectivity matrix vs. functionally-imaged orientation preference.",
    "effect_size": "p < 0.05 for connection preference",
    "text_access": "fulltext",
    "study_system": "Mouse V1 (visual cortex); electron microscopy; two-photon imaging; layer L2/3; pyramidal cells",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Therefore, the preferential connectivity (, red versus blue line,< 0.05, red versus black line,< 0.05, Permutation tests; and 2f,< 0.05, Cochran–Armitage test) between neurons with similar orientation preferences must be the result of mechanisms that take place at the scale of spines: ~1 to 5 μm.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1038/s41586-025-08840-3",
      "10.1038/nature09802"
    ],
    "effect_size_source_sentence": "Therefore, the preferential connectivity (, red versus blue line,< 0.05, red versus black line,< 0.05, Permutation tests; and 2f,< 0.05, Cochran–Armitage test) between neurons with similar orientation preferences must be the result of mechanisms that take place at the scale of spines: ~1 to 5 μm."
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_06_evidence_package.json",
  "effect_size": "p < 0.05 for connection preference",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-06-connectomic-micons",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-d2a8c6775359"
  ],
  "source_span": "Therefore, the preferential connectivity (, red versus blue line,< 0.05, red versus black line,< 0.05, Permutation tests; and 2f,< 0.05, Cochran–Armitage test) between neurons with similar orientation preferences must be the result of mechanisms that take place at the scale of spines: ~1 to 5 μm.",
  "study_system": "Mouse V1 (visual cortex); electron microscopy; two-photon imaging; layer L2/3; pyramidal cells",
  "evidence_refs": [
    {
      "ref": "paper:paper-d2a8c6775359"
    }
  ],
  "section_title": "6. Connectomic resolution — MICrONS mouse V1/HVA millimetre-scale EM volume; pyramidal-pyramidal wiring statistics derived from it; reconciliation with paired-recording estimates",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Permutation and Cochran–Armitage tests on EM-reconstructed L2/3 excitatory connectivity matrix vs. functionally-imaged orientation preference.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-06-connectomic-micons",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_06_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}