Details
- scope
- Mouse V1 (visual cortex); electron microscopy; two-photon imaging; layer L2/3; pyramidal cells
- claim_text
- Combined two-photon calcium imaging and EM reconstruction of mouse V1 L2/3 found preferential excitatory connectivity between pyramidal cells with similar orientation preferences operates at the spine scale (~1–5 μm).
- section_id
- section_06
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_06_evidence_package.json
- effect_size
- p < 0.05 for connection preference
- review_repo
- ComputationalReviewRecurrence
- section_ref
- wiki_page:computationalreviewrecurrence-06-connectomic-micons
- source_kind
- review_finding
- source_path
- evidence/section_06_evidence_package.json
- study_system
- Mouse V1 (visual cortex); electron microscopy; two-photon imaging; layer L2/3; pyramidal cells
- section_title
- 6. Connectomic resolution — MICrONS mouse V1/HVA millimetre-scale EM volume; pyramidal-pyramidal wiring statistics derived from it; reconciliation with paired-recording estimates
- evidence_summary
- Permutation and Cochran–Armitage tests on EM-reconstructed L2/3 excitatory connectivity matrix vs. functionally-imaged orientation preference.
- review_bundle_ref
- analysis_bundle:ab-d9c479db9be9
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-d9c479db9be9
- source_artifact_ref
- wiki_page:computationalreviewrecurrence-06-connectomic-micons
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_06_evidence_package.json
- commit_sha
- 79ce062d54a924ce05953ec90aa9d26044d2b48f
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (5)
- raw_fields
{ "n": 1278, "doi": "10.1038/nature17192", "claim": "Combined two-photon calcium imaging and EM reconstruction of mouse V1 L2/3 found preferential excitatory connectivity between pyramidal cells with similar orientation preferences operates at the spine scale (~1–5 μm).", "cite_key": "Lee2016", "evidence": "Permutation and Cochran–Armitage tests on EM-reconstructed L2/3 excitatory connectivity matrix vs. functionally-imaged orientation preference.", "effect_size": "p < 0.05 for connection preference", "text_access": "fulltext", "study_system": "Mouse V1 (visual cortex); electron microscopy; two-photon imaging; layer L2/3; pyramidal cells", "argument_role": "supporting", "replication_status": "independently_replicated", "claim_source_sentence": "Therefore, the preferential connectivity (, red versus blue line,< 0.05, red versus black line,< 0.05, Permutation tests; and 2f,< 0.05, Cochran–Armitage test) between neurons with similar orientation preferences must be the result of mechanisms that take place at the scale of spines: ~1 to 5 μm.", "source_provenance_status": "ok", "replication_evidence_dois": [ "10.1038/s41586-025-08840-3", "10.1038/nature09802" ], "effect_size_source_sentence": "Therefore, the preferential connectivity (, red versus blue line,< 0.05, red versus black line,< 0.05, Permutation tests; and 2f,< 0.05, Cochran–Armitage test) between neurons with similar orientation preferences must be the result of mechanisms that take place at the scale of spines: ~1 to 5 μm." }- source_refs
[ "paper:paper-d2a8c6775359" ]
- source_span
Therefore, the preferential connectivity (, red versus blue line,< 0.05, red versus black line,< 0.05, Permutation tests; and 2f,< 0.05, Cochran–Armitage test) between neurons with similar orientation preferences must be the result of mechanisms that take place at the scale of spines: ~1 to 5 μm.
- evidence_refs
[ { "ref": "paper:paper-d2a8c6775359" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }