Version history

{
  "scope": "Mouse cortex; modeling of GEVI 2P voltage imaging (JEDI-2P), with empirical 1P vs 2P measurements",
  "claim_text": "Two-photon voltage imaging in mouse cortex is shot-noise- and photodamage-limited: for JEDI-2P with SNR 10, 1 kHz bandwidth, 200 mW laser power, and >300 µm depth, an 80-MHz 2P source can record from at most ~12 neurons simultaneously.",
  "raw_fields": {
    "n": 12,
    "doi": "10.1117/1.nph.11.3.035007",
    "claim": "Two-photon voltage imaging in mouse cortex is shot-noise- and photodamage-limited: for JEDI-2P with SNR 10, 1 kHz bandwidth, 200 mW laser power, and >300 µm depth, an 80-MHz 2P source can record from at most ~12 neurons simultaneously.",
    "cite_key": "PhilBrooks2024",
    "evidence": "Quantitative resolution-limit calculation for 2P voltage imaging — directly addresses the cluster_14 topic that voltage imaging cannot deliver the simultaneous, large-population subthreshold readout some E→E claims would require.",
    "effect_size": "~12 simultaneously recordable neurons (>300 µm depth, 200 mW, 80 MHz, SNR 10, 1 kHz)",
    "text_access": "abstract_only",
    "study_system": "Mouse cortex; modeling of GEVI 2P voltage imaging (JEDI-2P), with empirical 1P vs 2P measurements",
    "argument_role": "supporting",
    "replication_status": "single-study",
    "claim_source_sentence": "For voltage imaging with JEDI-2P in the mouse cortex with a target SNR of 10 (spike height to baseline shot noise), a measurement bandwidth of 1 kHz, a thermally limited laser power of 200 mW, and an imaging depth of > 300    μ m  , 2P voltage imaging using an 80-MHz source can record from no more than ∼ 12  neurons simultaneously.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "2P voltage imaging using an 80-MHz source can record from no more than ∼ 12  neurons simultaneously."
  },
  "section_id": "section_16",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_16_evidence_package.json",
  "effect_size": "~12 simultaneously recordable neurons (>300 µm depth, 200 mW, 80 MHz, SNR 10, 1 kHz)",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-16-synthesis",
  "source_kind": "review_finding",
  "source_path": "evidence/section_16_evidence_package.json",
  "source_refs": [
    "paper:paper-ed927db80f97"
  ],
  "source_span": "For voltage imaging with JEDI-2P in the mouse cortex with a target SNR of 10 (spike height to baseline shot noise), a measurement bandwidth of 1 kHz, a thermally limited laser power of 200 mW, and an imaging depth of > 300 μ m , 2P voltage imaging using an 80-MHz source can record from no more than ∼ 12 neurons simultaneously.",
  "study_system": "Mouse cortex; modeling of GEVI 2P voltage imaging (JEDI-2P), with empirical 1P vs 2P measurements",
  "evidence_refs": [
    {
      "ref": "paper:paper-ed927db80f97"
    }
  ],
  "section_title": "16. Synthesis — which computational claims the mouse-cortex E→E empirical record actually supports, where the bottleneck observations are, and what an inhibition-free, single-species, basic-research analytic framing misses",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Quantitative resolution-limit calculation for 2P voltage imaging — directly addresses the cluster_14 topic that voltage imaging cannot deliver the simultaneous, large-population subthreshold readout some E→E claims would require.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-16-synthesis",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_16_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}