Details
- scope
- Mouse cortex; modeling of GEVI 2P voltage imaging (JEDI-2P), with empirical 1P vs 2P measurements
- claim_text
- Two-photon voltage imaging in mouse cortex is shot-noise- and photodamage-limited: for JEDI-2P with SNR 10, 1 kHz bandwidth, 200 mW laser power, and >300 µm depth, an 80-MHz 2P source can record from at most ~12 neurons simultaneously.
- section_id
- section_16
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_16_evidence_package.json
- effect_size
- ~12 simultaneously recordable neurons (>300 µm depth, 200 mW, 80 MHz, SNR 10, 1 kHz)
- review_repo
- ComputationalReviewRecurrence
- section_ref
- wiki_page:computationalreviewrecurrence-16-synthesis
- source_kind
- review_finding
- source_path
- evidence/section_16_evidence_package.json
- study_system
- Mouse cortex; modeling of GEVI 2P voltage imaging (JEDI-2P), with empirical 1P vs 2P measurements
- section_title
- 16. Synthesis — which computational claims the mouse-cortex E→E empirical record actually supports, where the bottleneck observations are, and what an inhibition-free, single-species, basic-research analytic framing misses
- evidence_summary
- Quantitative resolution-limit calculation for 2P voltage imaging — directly addresses the cluster_14 topic that voltage imaging cannot deliver the simultaneous, large-population subthreshold readout some E→E claims would require.
- review_bundle_ref
- analysis_bundle:ab-d9c479db9be9
- replication_status
- single-study
- review_package_ref
- analysis_bundle:ab-d9c479db9be9
- source_artifact_ref
- wiki_page:computationalreviewrecurrence-16-synthesis
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_16_evidence_package.json
- commit_sha
- 79ce062d54a924ce05953ec90aa9d26044d2b48f
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (5)
- raw_fields
{ "n": 12, "doi": "10.1117/1.nph.11.3.035007", "claim": "Two-photon voltage imaging in mouse cortex is shot-noise- and photodamage-limited: for JEDI-2P with SNR 10, 1 kHz bandwidth, 200 mW laser power, and >300 µm depth, an 80-MHz 2P source can record from at most ~12 neurons simultaneously.", "cite_key": "PhilBrooks2024", "evidence": "Quantitative resolution-limit calculation for 2P voltage imaging — directly addresses the cluster_14 topic that voltage imaging cannot deliver the simultaneous, large-population subthreshold readout some E→E claims would require.", "effect_size": "~12 simultaneously recordable neurons (>300 µm depth, 200 mW, 80 MHz, SNR 10, 1 kHz)", "text_access": "abstract_only", "study_system": "Mouse cortex; modeling of GEVI 2P voltage imaging (JEDI-2P), with empirical 1P vs 2P measurements", "argument_role": "supporting", "replication_status": "single-study", "claim_source_sentence": "For voltage imaging with JEDI-2P in the mouse cortex with a target SNR of 10 (spike height to baseline shot noise), a measurement bandwidth of 1 kHz, a thermally limited laser power of 200 mW, and an imaging depth of > 300 μ m , 2P voltage imaging using an 80-MHz source can record from no more than ∼ 12 neurons simultaneously.", "source_provenance_status": "non_substring_match", "replication_evidence_dois": [], "effect_size_source_sentence": "2P voltage imaging using an 80-MHz source can record from no more than ∼ 12 neurons simultaneously." }- source_refs
[ "paper:paper-ed927db80f97" ]
- source_span
For voltage imaging with JEDI-2P in the mouse cortex with a target SNR of 10 (spike height to baseline shot noise), a measurement bandwidth of 1 kHz, a thermally limited laser power of 200 mW, and an imaging depth of > 300 μ m , 2P voltage imaging using an 80-MHz source can record from no more than ∼ 12 neurons simultaneously.
- evidence_refs
[ { "ref": "paper:paper-ed927db80f97" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }