Version history

{
  "scope": "Cortical network model — theoretical analysis applicable to mouse cortex circuits",
  "claim_text": "Local imbalance between excitation and inhibition in recurrent cortical networks gives rise to a distinct amplification mechanism ('imbalanced amplification') that produces purely excitatory or purely inhibitory population responses to stimuli, complementing balanced amplification as a recurrent-network mechanism.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1371/journal.pcbi.1006048",
    "claim": "Local imbalance between excitation and inhibition in recurrent cortical networks gives rise to a distinct amplification mechanism ('imbalanced amplification') that produces purely excitatory or purely inhibitory population responses to stimuli, complementing balanced amplification as a recurrent-network mechanism.",
    "cite_key": "Ebsch2018",
    "evidence": "Mean-field analysis of balanced spiking E-I networks with finite-size correction; demonstrates the mechanism in models of orientation tuning and surround suppression in cortex.",
    "effect_size": "qualitative — analytic finite-size correction to mean-field balance",
    "text_access": "fulltext",
    "study_system": "Cortical network model — theoretical analysis applicable to mouse cortex circuits",
    "argument_role": "supporting",
    "replication_status": "within_lab",
    "claim_source_sentence": "We show that cortical circuits with structure that is incompatible with balance are susceptible to an amplification mechanism arising when excitatory-inhibitory balance is broken at the level of local subpopulations, but maintained at a global level.",
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    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
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  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "effect_size": "qualitative — analytic finite-size correction to mean-field balance",
  "review_repo": "ComputationalReviewRecurrence",
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    "paper:paper-b08395331756"
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  "source_span": "We show that cortical circuits with structure that is incompatible with balance are susceptible to an amplification mechanism arising when excitatory-inhibitory balance is broken at the level of local subpopulations, but maintained at a global level.",
  "study_system": "Cortical network model — theoretical analysis applicable to mouse cortex circuits",
  "evidence_refs": [
    {
      "ref": "paper:paper-b08395331756"
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  "section_title": "9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation",
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    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
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  "evidence_summary": "Mean-field analysis of balanced spiking E-I networks with finite-size correction; demonstrates the mechanism in models of orientation tuning and surround suppression in cortex.",
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  "replication_status": "within_lab",
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  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}