Local imbalance between excitation and inhibition in recurrent cortical network…

Local imbalance between excitation and inhibition in recurrent cortical networks gives rise to a distinct amplification mechanism ('imbalanced amplification') that produces purely excitatory or purely inhibitory population responses to stimuli, complementing balanced amplification as a recurrent-network mechanism.

{
  "n": 0,
  "doi": "10.1371/journal.pcbi.1006048",
  "claim": "Local imbalance between excitation and inhibition in recurrent cortical networks gives rise to a distinct amplification mechanism ('imbalanced amplification') that produces purely excitatory or purely inhibitory population responses to stimuli, complementing balanced amplification as a recurrent-network mechanism.",
  "cite_key": "Ebsch2018",
  "evidence": "Mean-field analysis of balanced spiking E-I networks with finite-size correction; demonstrates the mechanism in models of orientation tuning and surround suppression in cortex.",
  "effect_size": "qualitative — analytic finite-size correction to mean-field balance",
  "text_access": "fulltext",
  "study_system": "Cortical network model — theoretical analysis applicable to mouse cortex circuits",
  "argument_role": "supporting",
  "replication_status": "within_lab",
  "claim_source_sentence": "We show that cortical circuits with structure that is incompatible with balance are susceptible to an amplification mechanism arising when excitatory-inhibitory balance is broken at the level of local subpopulations, but maintained at a global level.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
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  "paper:paper-b08395331756"
]

We show that cortical circuits with structure that is incompatible with balance are susceptible to an amplification mechanism arising when excitatory-inhibitory balance is broken at the level of local subpopulations, but maintained at a global level.

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