- claim_text
Each Kv3 channel gene generates multiple protein isoforms that are differentially regulated by protein kinases, with PKA and PKC phosphorylation capable of shifting Kv3 channel activation and modulating fast-spiking properties of interneurons.
- raw_fields
{
"n": 0,
"doi": "10.1152/physrev.00002.2017",
"claim": "Each Kv3 channel gene generates multiple protein isoforms that are differentially regulated by protein kinases, with PKA and PKC phosphorylation capable of shifting Kv3 channel activation and modulating fast-spiking properties of interneurons.",
"evidence": "Review of Kv3 channel modulation showing that phosphorylation can dynamically tune fast-spiking properties in response to neuromodulatory signals.",
"effect_size": "PKA/PKC phosphorylation shifts Kv3 activation, dynamically modulating FS properties",
"text_access": "fulltext",
"study_system": "Kv3 channels in neurons (review)",
"replication_status": "independently_replicated",
"claim_source_sentence": "The different Kv3 channels have unique expression patterns and biophysical properties and are regulated in different ways by protein kinases.",
"replication_evidence_dois": [
"10.1523/jneurosci.19-21-09332.1999"
],
"effect_size_source_sentence": "The different Kv3 channels have unique expression patterns and biophysical properties and are regulated in different ways by protein kinases."
}- source_refs
[
"paper:paper-52be420ef14e"
]
- evidence_refs
[
{
"ref": "paper:paper-52be420ef14e"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}