Version history

{
  "scope": "Kv3 channels in neurons (review)",
  "claim_text": "Each Kv3 channel gene generates multiple protein isoforms that are differentially regulated by protein kinases, with PKA and PKC phosphorylation capable of shifting Kv3 channel activation and modulating fast-spiking properties of interneurons.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1152/physrev.00002.2017",
    "claim": "Each Kv3 channel gene generates multiple protein isoforms that are differentially regulated by protein kinases, with PKA and PKC phosphorylation capable of shifting Kv3 channel activation and modulating fast-spiking properties of interneurons.",
    "evidence": "Review of Kv3 channel modulation showing that phosphorylation can dynamically tune fast-spiking properties in response to neuromodulatory signals.",
    "effect_size": "PKA/PKC phosphorylation shifts Kv3 activation, dynamically modulating FS properties",
    "text_access": "fulltext",
    "study_system": "Kv3 channels in neurons (review)",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "The different Kv3 channels have unique expression patterns and biophysical properties and are regulated in different ways by protein kinases.",
    "replication_evidence_dois": [
      "10.1523/jneurosci.19-21-09332.1999"
    ],
    "effect_size_source_sentence": "The different Kv3 channels have unique expression patterns and biophysical properties and are regulated in different ways by protein kinases."
  },
  "section_id": "section_05_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "effect_size": "PKA/PKC phosphorylation shifts Kv3 activation, dynamically modulating FS properties",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-05",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-52be420ef14e"
  ],
  "source_span": "The different Kv3 channels have unique expression patterns and biophysical properties and are regulated in different ways by protein kinases.",
  "study_system": "Kv3 channels in neurons (review)",
  "evidence_refs": [
    {
      "ref": "paper:paper-52be420ef14e"
    }
  ],
  "section_title": "Intrinsic Electrophysiology: The Fast-Spiking Phenotype and Its Variants",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Review of Kv3 channel modulation showing that phosphorylation can dynamically tune fast-spiking properties in response to neuromodulatory signals.",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-05",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}