Version history

{
  "scope": "rat S1 barrel column (cell-type-specific bouton quantification)",
  "claim_text": "In a rat S1 barrel column, every excitatory neuron type receives substantial thalamocortical innervation (~90–580 boutons per neuron); thick-tufted L5 pyramidal cells receive comparable VPM and POm bouton numbers (~300 each).",
  "raw_fields": {
    "n": 580,
    "doi": "10.1093/cercor/bhq069",
    "claim": "In a rat S1 barrel column, every excitatory neuron type receives substantial thalamocortical innervation (~90–580 boutons per neuron); thick-tufted L5 pyramidal cells receive comparable VPM and POm bouton numbers (~300 each).",
    "cite_key": "Meyer2010",
    "evidence": "Synaptophysin-EGFP labeling combined with reconstructed biocytin-filled neurons quantifying VPM/POm boutons onto each cell class in rat S1.",
    "effect_size": "~300 VPM boutons + ~300 POm boutons per L5 thick-tufted pyramidal neuron",
    "text_access": "fulltext",
    "study_system": "rat S1 barrel column (cell-type-specific bouton quantification)",
    "source_cluster_id": "cluster_05",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "We found that all types of excitatory neurons potentially receive substantial TC input (90-580 boutons per neuron); 2) pyramidal neurons in L3-L6 receive dual TC input from both VPM and POm that is potentially of equal magnitude for thick-tufted L5 pyramidal neurons (ca. 300 boutons each from VPM and POm); 3) L3, L4, and L5 pyramidal neurons have multiple (2-4) subcellular TC innervation domains that match the dendritic compartments of pyramidal cells; and 4) a subtype of thick-tufted L5 pyramidal neurons has an additional VPM innervation domain in L4.",
    "replication_evidence_dois": [
      "10.1093/cercor/bhn259",
      "10.7554/elife.44158"
    ],
    "effect_size_source_sentence": "pyramidal neurons in L3-L6 receive dual TC input from both VPM and POm that is potentially of equal magnitude for thick-tufted L5 pyramidal neurons (ca. 300 boutons each from VPM and POm)"
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json",
  "effect_size": "~300 VPM boutons + ~300 POm boutons per L5 thick-tufted pyramidal neuron",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-06",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-e5d5db2e3c24"
  ],
  "source_span": "We found that all types of excitatory neurons potentially receive substantial TC input (90-580 boutons per neuron); 2) pyramidal neurons in L3-L6 receive dual TC input from both VPM and POm that is potentially of equal magnitude for thick-tufted L5 pyramidal neurons (ca. 300 boutons each from VPM and POm); 3) L3, L4, and L5 pyramidal neurons have multiple (2-4) subcellular TC innervation domains that match the dendr...",
  "study_system": "rat S1 barrel column (cell-type-specific bouton quantification)",
  "evidence_refs": [
    {
      "ref": "paper:paper-e5d5db2e3c24"
    }
  ],
  "section_title": "Thalamic Feedback: Closing the Loop",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Synaptophysin-EGFP labeling combined with reconstructed biocytin-filled neurons quantifying VPM/POm boutons onto each cell class in rat S1.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-06",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}