Version history

{
  "scope": "human fetal brain, 5-23 gestational weeks",
  "claim_text": "Human neocortical interneurons have multiple origins including dorsal cortical progenitors expressing Nkx2.1, Dlx1/2, Lhx6, and Mash1, unlike in rodents where MGE is the primary source",
  "raw_fields": {
    "n": 0,
    "doi": "10.1093/cercor/bhq245",
    "claim": "Human neocortical interneurons have multiple origins including dorsal cortical progenitors expressing Nkx2.1, Dlx1/2, Lhx6, and Mash1, unlike in rodents where MGE is the primary source",
    "evidence": "Nkx2.1, Dlx1/2, Lhx6, and Mash1 expressed in human neocortical VZ/SVZ through midgestation; Ki67 shows proliferating calretinin+, Mash1+, and Nkx2.1+ cells in cortical progenitor zones",
    "effect_size": "expression retained in all fetal cortical layers up to 20 gestational weeks",
    "text_access": "abstract_only",
    "study_system": "human fetal brain, 5-23 gestational weeks",
    "replication_status": "contested",
    "claim_source_sentence": "these results suggest the existence of several categories of dorsal interneuronal progenitors in the human neocortical VZ/SVZ, in addition to ventrally derived cortical interneurons described in rodents",
    "replication_evidence_dois": [
      "10.1038/s41467-025-56058-8"
    ],
    "effect_size_source_sentence": "their expression was retained in cells of all fetal cortical layers up to midgestation (20 gw)"
  },
  "section_id": "section_03_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json",
  "effect_size": "expression retained in all fetal cortical layers up to 20 gestational weeks",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-03",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-a959e919a7c6"
  ],
  "source_span": "these results suggest the existence of several categories of dorsal interneuronal progenitors in the human neocortical VZ/SVZ, in addition to ventrally derived cortical interneurons described in rodents",
  "study_system": "human fetal brain, 5-23 gestational weeks",
  "evidence_refs": [
    {
      "ref": "paper:paper-a959e919a7c6"
    }
  ],
  "section_title": "Developmental Origins: MGE Lineage, Specification, and Migration",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Nkx2.1, Dlx1/2, Lhx6, and Mash1 expressed in human neocortical VZ/SVZ through midgestation; Ki67 shows proliferating calretinin+, Mash1+, and Nkx2.1+ cells in cortical progenitor zones",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "contested",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-03",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}