Human neocortical interneurons have multiple origins including dorsal cortical…

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scope: human fetal brain, 5-23 gestational weeks
claim_text: Human neocortical interneurons have multiple origins including dorsal cortical progenitors expressing Nkx2.1, Dlx1/2, Lhx6, and Mash1, unlike in rodents where MGE is the primary source
section_id: section_03_evidence_package
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
effect_size: expression retained in all fetal cortical layers up to 20 gestational weeks
review_repo: ComputationalReviewPV
section_ref: wiki_page:computationalreviewpv-03
source_kind: review_finding
source_path: evidence/section_03_evidence_package.json
source_span: these results suggest the existence of several categories of dorsal interneuronal progenitors in the human neocortical VZ/SVZ, in addition to ventrally derived cortical interneurons described in rodents
study_system: human fetal brain, 5-23 gestational weeks
section_title: Developmental Origins: MGE Lineage, Specification, and Migration
evidence_summary: Nkx2.1, Dlx1/2, Lhx6, and Mash1 expressed in human neocortical VZ/SVZ through midgestation; Ki67 shows proliferating calretinin+, Mash1+, and Nkx2.1+ cells in cortical progenitor zones
review_bundle_ref: analysis_bundle:ab-e6261c8263e7
replication_status: contested
review_package_ref: analysis_bundle:ab-e6261c8263e7
source_artifact_ref: wiki_page:computationalreviewpv-03
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
commit_sha: df9fc7e8d455b084152c9d713558dae0013cef21
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1093/cercor/bhq245",
  "claim": "Human neocortical interneurons have multiple origins including dorsal cortical progenitors expressing Nkx2.1, Dlx1/2, Lhx6, and Mash1, unlike in rodents where MGE is the primary source",
  "evidence": "Nkx2.1, Dlx1/2, Lhx6, and Mash1 expressed in human neocortical VZ/SVZ through midgestation; Ki67 shows proliferating calretinin+, Mash1+, and Nkx2.1+ cells in cortical progenitor zones",
  "effect_size": "expression retained in all fetal cortical layers up to 20 gestational weeks",
  "text_access": "abstract_only",
  "study_system": "human fetal brain, 5-23 gestational weeks",
  "replication_status": "contested",
  "claim_source_sentence": "these results suggest the existence of several categories of dorsal interneuronal progenitors in the human neocortical VZ/SVZ, in addition to ventrally derived cortical interneurons described in rodents",
  "replication_evidence_dois": [
    "10.1038/s41467-025-56058-8"
  ],
  "effect_size_source_sentence": "their expression was retained in cells of all fetal cortical layers up to midgestation (20 gw)"
}

source_refs

[
  "paper:paper-a959e919a7c6"
]

evidence_refs

[
  {
    "ref": "paper:paper-a959e919a7c6"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

Human neocortical interneurons have multiple origins including dorsal cortical…

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