CRACM mapping in mouse barrel cortex and vibrissal motor cortex shows that vS1…

CRACM mapping in mouse barrel cortex and vibrissal motor cortex shows that vS1 axons preferentially target upper-layer L2/3 and L5A pyramidal neurons in vM1 (including neurons projecting back to vS1) and only weakly target deeper L5B and L6, defining laminar logic of the S1↔M1 cortico-cortical loop.

{
  "n": null,
  "doi": "10.1016/j.neuron.2011.07.029",
  "claim": "CRACM mapping in mouse barrel cortex and vibrissal motor cortex shows that vS1 axons preferentially target upper-layer L2/3 and L5A pyramidal neurons in vM1 (including neurons projecting back to vS1) and only weakly target deeper L5B and L6, defining laminar logic of the S1↔M1 cortico-cortical loop.",
  "cite_key": "Mao2011",
  "evidence": "ChR2 expression + anterograde and retrograde labelling + CRACM mapping of cortico-cortical synaptic strength between mouse vS1 and vM1.",
  "effect_size": "S1→M1 input strongest in L2/3 and L5A; particularly strong onto M1→S1-projecting cells; weaker input to L5B/L6.",
  "text_access": "abstract_only",
  "study_system": "Mouse vS1 ↔ vM1; CRACM circuit mapping.",
  "argument_role": "supporting",
  "replication_status": "replicated",
  "claim_source_sentence": "Barrel cortex axons preferentially targeted upper layer (L2/3, L5A) neurons in motor cortex; input to neurons projecting back to barrel cortex was particularly strong.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1038/nature11321"
  ],
  "effect_size_source_sentence": "Barrel cortex axons preferentially targeted upper layer (L2/3, L5A) neurons in motor cortex; input to neurons projecting back to barrel cortex was particularly strong."
}

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