Version history

{
  "scope": "mouse prelimbic PFC slice; cell-type optogenetics",
  "claim_text": "In mouse prelimbic PFC, mu (MOR) and delta (DOR) opioid receptors differentially regulate GABA release from PV, SST, CCK, and VIP interneurons; this cell-type-specific neuromodulation provides a substrate for opioid-dependent gating of cortical inhibitory rhythms via VIP and other interneuron classes.",
  "raw_fields": {
    "n": null,
    "doi": "10.1523/jneurosci.1963-24.2025",
    "pmid": "40393805",
    "year": "2025",
    "claim": "In mouse prelimbic PFC, mu (MOR) and delta (DOR) opioid receptors differentially regulate GABA release from PV, SST, CCK, and VIP interneurons; this cell-type-specific neuromodulation provides a substrate for opioid-dependent gating of cortical inhibitory rhythms via VIP and other interneuron classes.",
    "pmcid": "PMC12225597",
    "title": "Opioid Receptors Modulate Inhibition within the Prefrontal Cortex through Dissociable Cellular and Molecular Mechanisms.",
    "authors": "",
    "journal": "",
    "cite_key": "Cole2025",
    "evidence": "Cell-type optogenetics + slice electrophysiology in male/female mice prelimbic PFC, layer 2/3.",
    "cluster_id": "cluster_09_oscillations",
    "effect_size": "DOR more effective on spontaneous IPSCs; MOR more effective on electrically-evoked GABA",
    "figure_data": [],
    "text_access": "abstract_only",
    "study_system": "mouse prelimbic PFC slice; cell-type optogenetics",
    "cited_by_count": null,
    "_source_cluster": "cluster_09_oscillations",
    "replication_status": "single-study",
    "_source_cluster_index": 39,
    "claim_source_sentence": "Cell type-specific optogenetics revealed that MOR and DOR differentially regulate inhibitory transmission from parvalbumin, somatostatin, cholecystokinin, and vasoactive intestinal peptide-expressing INs.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "DOR activation is more effective at suppressing spontaneous inhibitory transmission in layer 2/3 of the prelimbic PFC, while MOR causes a greater acute suppression of electrically evoked GABA release"
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "effect_size": "DOR more effective on spontaneous IPSCs; MOR more effective on electrically-evoked GABA",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-208bbf2a3ba6"
  ],
  "source_span": "Cell type-specific optogenetics revealed that MOR and DOR differentially regulate inhibitory transmission from parvalbumin, somatostatin, cholecystokinin, and vasoactive intestinal peptide-expressing INs.",
  "study_system": "mouse prelimbic PFC slice; cell-type optogenetics",
  "evidence_refs": [
    {
      "ref": "paper:paper-208bbf2a3ba6"
    }
  ],
  "section_title": "Oscillatory Dynamics and Temporal Coordination",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Cell-type optogenetics + slice electrophysiology in male/female mice prelimbic PFC, layer 2/3.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}