In mouse prelimbic PFC, mu (MOR) and delta (DOR) opioid receptors differentiall…

In mouse prelimbic PFC, mu (MOR) and delta (DOR) opioid receptors differentially regulate GABA release from PV, SST, CCK, and VIP interneurons; this cell-type-specific neuromodulation provides a substrate for opioid-dependent gating of cortical inhibitory rhythms via VIP and other interneuron classes.

{
  "n": null,
  "doi": "10.1523/jneurosci.1963-24.2025",
  "pmid": "40393805",
  "year": "2025",
  "claim": "In mouse prelimbic PFC, mu (MOR) and delta (DOR) opioid receptors differentially regulate GABA release from PV, SST, CCK, and VIP interneurons; this cell-type-specific neuromodulation provides a substrate for opioid-dependent gating of cortical inhibitory rhythms via VIP and other interneuron classes.",
  "pmcid": "PMC12225597",
  "title": "Opioid Receptors Modulate Inhibition within the Prefrontal Cortex through Dissociable Cellular and Molecular Mechanisms.",
  "authors": "",
  "journal": "",
  "cite_key": "Cole2025",
  "evidence": "Cell-type optogenetics + slice electrophysiology in male/female mice prelimbic PFC, layer 2/3.",
  "cluster_id": "cluster_09_oscillations",
  "effect_size": "DOR more effective on spontaneous IPSCs; MOR more effective on electrically-evoked GABA",
  "figure_data": [],
  "text_access": "abstract_only",
  "study_system": "mouse prelimbic PFC slice; cell-type optogenetics",
  "cited_by_count": null,
  "_source_cluster": "cluster_09_oscillations",
  "replication_status": "single-study",
  "_source_cluster_index": 39,
  "claim_source_sentence": "Cell type-specific optogenetics revealed that MOR and DOR differentially regulate inhibitory transmission from parvalbumin, somatostatin, cholecystokinin, and vasoactive intestinal peptide-expressing INs.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "DOR activation is more effective at suppressing spontaneous inhibitory transmission in layer 2/3 of the prelimbic PFC, while MOR causes a greater acute suppression of electrically evoked GABA release"
}

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]

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