Version history

{
  "scope": "Mouse V1 with LM (higher visual area) cortico-cortical feedback; all-optical and two-photon imaging",
  "claim_text": "Cortico-cortical feedback from LM to V1 in mouse is spatially organized in visual coordinates and engages regenerative apical-tuft dendritic events in V1 pyramidal neurons.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/s41586-023-06007-6",
    "claim": "Cortico-cortical feedback from LM to V1 in mouse is spatially organized in visual coordinates and engages regenerative apical-tuft dendritic events in V1 pyramidal neurons.",
    "cite_key": "Fisek2023",
    "evidence": "Long-range all-optical connectivity mapping plus two-photon calcium imaging of V1 dendrites with optogenetic activation of LM→V1 projections.",
    "effect_size": "Same-retinotopy feedback is relatively suppressive; offset-retinotopy feedback is relatively facilitating (qualitative spatial polarity).",
    "text_access": "abstract_only",
    "study_system": "Mouse V1 with LM (higher visual area) cortico-cortical feedback; all-optical and two-photon imaging",
    "argument_role": "supporting",
    "replication_status": "single-study",
    "claim_source_sentence": "Two-photon calcium imaging data show that this facilitating feedback is nonlinearly integrated in the apical tuft dendrites of V1 pyramidal neurons: retinotopically offset (surround) visual stimuli drive local dendritic calcium signals indicative of regenerative events, and two-photon optogenetic activation of LM neurons projecting to identified feedback-recipient spines in V1 can drive similar branch-specific local calcium signals.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "When the source and target of feedback represent the same area of visual space, feedback is relatively suppressive."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "effect_size": "Same-retinotopy feedback is relatively suppressive; offset-retinotopy feedback is relatively facilitating (qualitative spatial polarity).",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-95604f6d0bfb"
  ],
  "source_span": "Two-photon calcium imaging data show that this facilitating feedback is nonlinearly integrated in the apical tuft dendrites of V1 pyramidal neurons: retinotopically offset (surround) visual stimuli drive local dendritic calcium signals indicative of regenerative events, and two-photon optogenetic activation of LM neurons projecting to identified feedback-recipient spines in V1 can drive similar branch-specific local...",
  "study_system": "Mouse V1 with LM (higher visual area) cortico-cortical feedback; all-optical and two-photon imaging",
  "evidence_refs": [
    {
      "ref": "paper:paper-95604f6d0bfb"
    }
  ],
  "section_title": "8. Cross-areal mouse cortico-cortical excitatory connectivity — hierarchical feedforward and feedback as recurrent loops at the network level; Allen Mouse Connectivity Atlas anchored views",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Long-range all-optical connectivity mapping plus two-photon calcium imaging of V1 dendrites with optogenetic activation of LM→V1 projections.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}