- raw_fields
{
"n": null,
"doi": "10.1038/s41586-023-06007-6",
"claim": "Cortico-cortical feedback from LM to V1 in mouse is spatially organized in visual coordinates and engages regenerative apical-tuft dendritic events in V1 pyramidal neurons.",
"cite_key": "Fisek2023",
"evidence": "Long-range all-optical connectivity mapping plus two-photon calcium imaging of V1 dendrites with optogenetic activation of LM→V1 projections.",
"effect_size": "Same-retinotopy feedback is relatively suppressive; offset-retinotopy feedback is relatively facilitating (qualitative spatial polarity).",
"text_access": "abstract_only",
"study_system": "Mouse V1 with LM (higher visual area) cortico-cortical feedback; all-optical and two-photon imaging",
"argument_role": "supporting",
"replication_status": "single-study",
"claim_source_sentence": "Two-photon calcium imaging data show that this facilitating feedback is nonlinearly integrated in the apical tuft dendrites of V1 pyramidal neurons: retinotopically offset (surround) visual stimuli drive local dendritic calcium signals indicative of regenerative events, and two-photon optogenetic activation of LM neurons projecting to identified feedback-recipient spines in V1 can drive similar branch-specific local calcium signals.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": "When the source and target of feedback represent the same area of visual space, feedback is relatively suppressive."
}- source_refs
[
"paper:paper-95604f6d0bfb"
]
- source_span
Two-photon calcium imaging data show that this facilitating feedback is nonlinearly integrated in the apical tuft dendrites of V1 pyramidal neurons: retinotopically offset (surround) visual stimuli drive local dendritic calcium signals indicative of regenerative events, and two-photon optogenetic activation of LM neurons projecting to identified feedback-recipient spines in V1 can drive similar branch-specific local...
- evidence_refs
[
{
"ref": "paper:paper-95604f6d0bfb"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}