Disconnecting cat thalamic relay/intralaminar nuclei from nucleus reticularis t…

Disconnecting cat thalamic relay/intralaminar nuclei from nucleus reticularis thalami — by transection or kainate lesion — abolishes spindle-wave rhythmicity and the associated rhythmic IPSPs while sparing intrinsic burst firing, demonstrating that TRN is the pacemaker of thalamocortical spindles.

{
  "n": 0,
  "doi": "10.1152/jn.1985.54.6.1473",
  "claim": "Disconnecting cat thalamic relay/intralaminar nuclei from nucleus reticularis thalami — by transection or kainate lesion — abolishes spindle-wave rhythmicity and the associated rhythmic IPSPs while sparing intrinsic burst firing, demonstrating that TRN is the pacemaker of thalamocortical spindles.",
  "cite_key": "Steriade1985",
  "evidence": "Acute thalamic transection and chronic kainate-lesion experiments in cat with intracellular and extracellular recordings.",
  "effect_size": "Loss of 7–14 Hz spindle-wave rhythms recurring at 0.1–0.2 Hz in RE-disconnected nuclei and ipsilateral neocortex; preserved spindling in contralateral hemisphere",
  "text_access": "abstract_only",
  "study_system": "cat thalamic transection / TRN kainate lesion in vivo",
  "source_cluster_id": "cluster_05",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Two features distinguish RE-deprived nuclei from normal thalamic nuclei: absence of spindle-wave rhythmicity and all-burst activity of neurons.",
  "replication_evidence_dois": [
    "10.1152/jn.1994.72.2.803",
    "10.1126/science.8392750",
    "10.1146/annurev.neuro.20.1.185"
  ],
  "effect_size_source_sentence": "The abolition of spindle-related rhythms (sequences of 7- to 14-Hz waves recurring periodically with a rhythm of 0.1-0.2 Hz) in RE-disconnected thalamic nuclei and ipsilateral neocortical areas contrasted with normal spindling rhythmicity in contralateral EEG leads."
}

[
  "paper:paper-041bad5dabc6"
]

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  }
]

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