Version history

{
  "scope": "cat thalamic transection / TRN kainate lesion in vivo",
  "claim_text": "Disconnecting cat thalamic relay/intralaminar nuclei from nucleus reticularis thalami — by transection or kainate lesion — abolishes spindle-wave rhythmicity and the associated rhythmic IPSPs while sparing intrinsic burst firing, demonstrating that TRN is the pacemaker of thalamocortical spindles.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1152/jn.1985.54.6.1473",
    "claim": "Disconnecting cat thalamic relay/intralaminar nuclei from nucleus reticularis thalami — by transection or kainate lesion — abolishes spindle-wave rhythmicity and the associated rhythmic IPSPs while sparing intrinsic burst firing, demonstrating that TRN is the pacemaker of thalamocortical spindles.",
    "cite_key": "Steriade1985",
    "evidence": "Acute thalamic transection and chronic kainate-lesion experiments in cat with intracellular and extracellular recordings.",
    "effect_size": "Loss of 7–14 Hz spindle-wave rhythms recurring at 0.1–0.2 Hz in RE-disconnected nuclei and ipsilateral neocortex; preserved spindling in contralateral hemisphere",
    "text_access": "abstract_only",
    "study_system": "cat thalamic transection / TRN kainate lesion in vivo",
    "source_cluster_id": "cluster_05",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Two features distinguish RE-deprived nuclei from normal thalamic nuclei: absence of spindle-wave rhythmicity and all-burst activity of neurons.",
    "replication_evidence_dois": [
      "10.1152/jn.1994.72.2.803",
      "10.1126/science.8392750",
      "10.1146/annurev.neuro.20.1.185"
    ],
    "effect_size_source_sentence": "The abolition of spindle-related rhythms (sequences of 7- to 14-Hz waves recurring periodically with a rhythm of 0.1-0.2 Hz) in RE-disconnected thalamic nuclei and ipsilateral neocortical areas contrasted with normal spindling rhythmicity in contralateral EEG leads."
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json",
  "effect_size": "Loss of 7–14 Hz spindle-wave rhythms recurring at 0.1–0.2 Hz in RE-disconnected nuclei and ipsilateral neocortex; preserved spindling in contralateral hemisphere",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-06",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-041bad5dabc6"
  ],
  "source_span": "Two features distinguish RE-deprived nuclei from normal thalamic nuclei: absence of spindle-wave rhythmicity and all-burst activity of neurons.",
  "study_system": "cat thalamic transection / TRN kainate lesion in vivo",
  "evidence_refs": [
    {
      "ref": "paper:paper-041bad5dabc6"
    }
  ],
  "section_title": "Thalamic Feedback: Closing the Loop",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Acute thalamic transection and chronic kainate-lesion experiments in cat with intracellular and extracellular recordings.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-06",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}