Version history

{
  "scope": "mouse V1 with cingulate (Cg) inputs; in vitro + in vivo",
  "claim_text": "Cingulate (Cg) cortex projections to V1 preferentially recruit VIP interneurons in layer 2/3, producing spatially localized disinhibition by inhibition of SOM cells, and a top-down center-surround organization of pyramidal neuron responses.",
  "raw_fields": {
    "n": null,
    "doi": "10.1126/science.1254126",
    "claim": "Cingulate (Cg) cortex projections to V1 preferentially recruit VIP interneurons in layer 2/3, producing spatially localized disinhibition by inhibition of SOM cells, and a top-down center-surround organization of pyramidal neuron responses.",
    "title": null,
    "cite_key": "Zhang2014",
    "evidence": "Optogenetic activation of Cg axons in V1 with whole-cell recordings from VIP/SOM/PV/Pyr; in vivo two-photon imaging of receptive fields.",
    "effect_size": "Qualitative: stronger Cg-evoked input to VIP than other interneuron types in L2/3; >2× over Pyr (matched motor-to-S1 pattern).",
    "text_access": "fulltext",
    "study_system": "mouse V1 with cingulate (Cg) inputs; in vitro + in vivo",
    "_source_cluster": "cluster_05_synaptic_connectivity",
    "replication_status": "independently_replicated",
    "_source_cluster_index": 3,
    "claim_source_sentence": "In response to focal Cg axon activation, SOM+ and PV+ neurons inhibit pyramidal neurons over a broad cortical area (with SOM+ neurons as a major source of inhibition at 200 μm), whereas VIP+ neurons selectively enhance the responses at 0 μm through localized inhibition of SOM+ neurons ( , left).",
    "replication_evidence_dois": [
      "10.1038/nn.3544"
    ],
    "effect_size_source_sentence": "The Cg input was stronger in VIP+ than the other neuron types in layer 2/3 ( ), similar to the motor→somatosensory cortex input ( )."
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "effect_size": "Qualitative: stronger Cg-evoked input to VIP than other interneuron types in L2/3; >2× over Pyr (matched motor-to-S1 pattern).",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-05bd6c97da43"
  ],
  "source_span": "In response to focal Cg axon activation, SOM+ and PV+ neurons inhibit pyramidal neurons over a broad cortical area (with SOM+ neurons as a major source of inhibition at 200 μm), whereas VIP+ neurons selectively enhance the responses at 0 μm through localized inhibition of SOM+ neurons ( , left).",
  "study_system": "mouse V1 with cingulate (Cg) inputs; in vitro + in vivo",
  "evidence_refs": [
    {
      "ref": "paper:paper-05bd6c97da43"
    }
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Optogenetic activation of Cg axons in V1 with whole-cell recordings from VIP/SOM/PV/Pyr; in vivo two-photon imaging of receptive fields.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}