Cingulate (Cg) cortex projections to V1 preferentially recruit VIP interneurons…

{
  "n": null,
  "doi": "10.1126/science.1254126",
  "claim": "Cingulate (Cg) cortex projections to V1 preferentially recruit VIP interneurons in layer 2/3, producing spatially localized disinhibition by inhibition of SOM cells, and a top-down center-surround organization of pyramidal neuron responses.",
  "title": null,
  "cite_key": "Zhang2014",
  "evidence": "Optogenetic activation of Cg axons in V1 with whole-cell recordings from VIP/SOM/PV/Pyr; in vivo two-photon imaging of receptive fields.",
  "effect_size": "Qualitative: stronger Cg-evoked input to VIP than other interneuron types in L2/3; >2× over Pyr (matched motor-to-S1 pattern).",
  "text_access": "fulltext",
  "study_system": "mouse V1 with cingulate (Cg) inputs; in vitro + in vivo",
  "_source_cluster": "cluster_05_synaptic_connectivity",
  "replication_status": "independently_replicated",
  "_source_cluster_index": 3,
  "claim_source_sentence": "In response to focal Cg axon activation, SOM+ and PV+ neurons inhibit pyramidal neurons over a broad cortical area (with SOM+ neurons as a major source of inhibition at 200 μm), whereas VIP+ neurons selectively enhance the responses at 0 μm through localized inhibition of SOM+ neurons ( , left).",
  "replication_evidence_dois": [
    "10.1038/nn.3544"
  ],
  "effect_size_source_sentence": "The Cg input was stronger in VIP+ than the other neuron types in layer 2/3 ( ), similar to the motor→somatosensory cortex input ( )."
}

[
  "paper:paper-05bd6c97da43"
]

In response to focal Cg axon activation, SOM+ and PV+ neurons inhibit pyramidal neurons over a broad cortical area (with SOM+ neurons as a major source of inhibition at 200 μm), whereas VIP+ neurons selectively enhance the responses at 0 μm through localized inhibition of SOM+ neurons ( , left).

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    "ref": "paper:paper-05bd6c97da43"
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  "notes": [
    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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