Version history

{
  "scope": "human neurosurgical cortical slices L1; whole-cell + biocytin",
  "claim_text": "Human cortical layer 1 'rosehip' interneurons (a novel non-rodent CGE-derived type expressing CCK and LAMP5 transcriptomic markers but distinct from VIP cells) fire stuttering or irregular-spiking patterns from a resting potential of −61.3 ± 5.8 mV, with subthreshold oscillations tuned to beta–gamma frequencies (3.8–80 Hz).",
  "raw_fields": {
    "n": 10,
    "doi": "10.1038/s41593-018-0205-2",
    "claim": "Human cortical layer 1 'rosehip' interneurons (a novel non-rodent CGE-derived type expressing CCK and LAMP5 transcriptomic markers but distinct from VIP cells) fire stuttering or irregular-spiking patterns from a resting potential of −61.3 ± 5.8 mV, with subthreshold oscillations tuned to beta–gamma frequencies (3.8–80 Hz).",
    "title": null,
    "caveats": "Rosehip cells map to LAMP5 transcriptomic types (i5 cluster with weak r=0.34 to mouse Smad3) — they are CGE-derived but distinct from VIP. Included for cluster_04 because they sit on the same Sncg/Lamp5/Vip transcriptomic continuum and inform IS/stuttering firing diversity.",
    "cite_key": "Boldog2018",
    "evidence": "n = 10 rosehip cells whole-cell patched and biocytin-filled in human parietal/frontal/temporal cortex L1; subthreshold FFT analysis",
    "effect_size": "RMP −61.34 ± 5.8 mV (n=10); β/γ-tuned subthreshold oscillations 3.8–80 Hz",
    "text_access": "fulltext",
    "study_system": "human neurosurgical cortical slices L1; whole-cell + biocytin",
    "_source_cluster": "cluster_04_intrinsic_electrophysiology",
    "replication_status": "replication_unknown",
    "_source_cluster_index": 40,
    "claim_source_sentence": "Anatomically identified RCs responded to long (800 ms) suprathreshold current injections with stuttering or irregular spiking firing patterns 2 when activated from resting membrane potential (-61.34±5.8 mV, Fig.4A).",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "membrane oscillations and firing of RCs were tuned to beta and gamma frequencies (Fig.4E-G)."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "effect_size": "RMP −61.34 ± 5.8 mV (n=10); β/γ-tuned subthreshold oscillations 3.8–80 Hz",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-pm-30150662"
  ],
  "source_span": "Anatomically identified RCs responded to long (800 ms) suprathreshold current injections with stuttering or irregular spiking firing patterns 2 when activated from resting membrane potential (-61.34±5.8 mV, Fig.4A).",
  "study_system": "human neurosurgical cortical slices L1; whole-cell + biocytin",
  "evidence_refs": [
    {
      "ref": "paper:paper-pm-30150662"
    }
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "n = 10 rosehip cells whole-cell patched and biocytin-filled in human parietal/frontal/temporal cortex L1; subthreshold FFT analysis",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}