Human cortical layer 1 'rosehip' interneurons (a novel non-rodent CGE-derived t…

Human cortical layer 1 'rosehip' interneurons (a novel non-rodent CGE-derived type expressing CCK and LAMP5 transcriptomic markers but distinct from VIP cells) fire stuttering or irregular-spiking patterns from a resting potential of −61.3 ± 5.8 mV, with subthreshold oscillations tuned to beta–gamma frequencies (3.8–80 Hz).

{
  "n": 10,
  "doi": "10.1038/s41593-018-0205-2",
  "claim": "Human cortical layer 1 'rosehip' interneurons (a novel non-rodent CGE-derived type expressing CCK and LAMP5 transcriptomic markers but distinct from VIP cells) fire stuttering or irregular-spiking patterns from a resting potential of −61.3 ± 5.8 mV, with subthreshold oscillations tuned to beta–gamma frequencies (3.8–80 Hz).",
  "title": null,
  "caveats": "Rosehip cells map to LAMP5 transcriptomic types (i5 cluster with weak r=0.34 to mouse Smad3) — they are CGE-derived but distinct from VIP. Included for cluster_04 because they sit on the same Sncg/Lamp5/Vip transcriptomic continuum and inform IS/stuttering firing diversity.",
  "cite_key": "Boldog2018",
  "evidence": "n = 10 rosehip cells whole-cell patched and biocytin-filled in human parietal/frontal/temporal cortex L1; subthreshold FFT analysis",
  "effect_size": "RMP −61.34 ± 5.8 mV (n=10); β/γ-tuned subthreshold oscillations 3.8–80 Hz",
  "text_access": "fulltext",
  "study_system": "human neurosurgical cortical slices L1; whole-cell + biocytin",
  "_source_cluster": "cluster_04_intrinsic_electrophysiology",
  "replication_status": "replication_unknown",
  "_source_cluster_index": 40,
  "claim_source_sentence": "Anatomically identified RCs responded to long (800 ms) suprathreshold current injections with stuttering or irregular spiking firing patterns 2 when activated from resting membrane potential (-61.34±5.8 mV, Fig.4A).",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "membrane oscillations and firing of RCs were tuned to beta and gamma frequencies (Fig.4E-G)."
}

[
  "paper:paper-pm-30150662"
]

[
  {
    "ref": "paper:paper-pm-30150662"
  }
]

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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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