Version history

{
  "scope": "adult mouse MOp Patch-seq, ~P75",
  "claim_text": "Patch-seq across mouse primary motor cortex shows that intrinsic-electrophysiological properties of Vip transcriptomic types vary continuously rather than discretely along the transcriptomic axis — e.g., membrane time constant peaks at the Sncg-adjacent end and decreases toward Vip-Gpc3 — supporting a graded morpho-electric landscape within the VIP subclass.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/s41586-020-2907-3",
    "claim": "Patch-seq across mouse primary motor cortex shows that intrinsic-electrophysiological properties of Vip transcriptomic types vary continuously rather than discretely along the transcriptomic axis — e.g., membrane time constant peaks at the Sncg-adjacent end and decreases toward Vip-Gpc3 — supporting a graded morpho-electric landscape within the VIP subclass.",
    "title": null,
    "cite_key": "Scala2021",
    "evidence": "adult mouse MOp acute slices, Patch-seq (whole-cell intrinsic ephys + Smart-seq2 + morphology) across all layers and Cre lines",
    "effect_size": "qualitative — continuous gradient of τm across Vip t-types; ranked highest near Sncg, lowest at Vip Gpc3",
    "text_access": "fulltext",
    "study_system": "adult mouse MOp Patch-seq, ~P75",
    "_source_cluster": "cluster_04_intrinsic_electrophysiology",
    "replication_status": "replicated",
    "_source_cluster_index": 11,
    "claim_source_sentence": "For example, electrophysiological properties of the t-types within the Vip subclass varied continuously across the transcriptomic landscape; the membrane time constant, for instance, had its largest values close to the Sncg subclass and gradually decreased towards Vip Gpc3",
    "replication_evidence_dois": [
      "10.1126/science.adf6484",
      "10.1016/j.neuron.2021.08.030"
    ],
    "effect_size_source_sentence": "For example, electrophysiological properties of the t-types within the Vip subclass varied continuously across the transcriptomic landscape; the membrane time constant, for instance, had its largest values close to the Sncg subclass and gradually decreased towards Vip Gpc3"
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "effect_size": "qualitative — continuous gradient of τm across Vip t-types; ranked highest near Sncg, lowest at Vip Gpc3",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-be132b319290"
  ],
  "source_span": "For example, electrophysiological properties of the t-types within the Vip subclass varied continuously across the transcriptomic landscape; the membrane time constant, for instance, had its largest values close to the Sncg subclass and gradually decreased towards Vip Gpc3",
  "study_system": "adult mouse MOp Patch-seq, ~P75",
  "evidence_refs": [
    {
      "ref": "paper:paper-be132b319290"
    }
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "adult mouse MOp acute slices, Patch-seq (whole-cell intrinsic ephys + Smart-seq2 + morphology) across all layers and Cre lines",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}