Patch-seq across mouse primary motor cortex shows that intrinsic-electrophysiol…

Patch-seq across mouse primary motor cortex shows that intrinsic-electrophysiological properties of Vip transcriptomic types vary continuously rather than discretely along the transcriptomic axis — e.g., membrane time constant peaks at the Sncg-adjacent end and decreases toward Vip-Gpc3 — supporting a graded morpho-electric landscape within the VIP subclass.

{
  "n": null,
  "doi": "10.1038/s41586-020-2907-3",
  "claim": "Patch-seq across mouse primary motor cortex shows that intrinsic-electrophysiological properties of Vip transcriptomic types vary continuously rather than discretely along the transcriptomic axis — e.g., membrane time constant peaks at the Sncg-adjacent end and decreases toward Vip-Gpc3 — supporting a graded morpho-electric landscape within the VIP subclass.",
  "title": null,
  "cite_key": "Scala2021",
  "evidence": "adult mouse MOp acute slices, Patch-seq (whole-cell intrinsic ephys + Smart-seq2 + morphology) across all layers and Cre lines",
  "effect_size": "qualitative — continuous gradient of τm across Vip t-types; ranked highest near Sncg, lowest at Vip Gpc3",
  "text_access": "fulltext",
  "study_system": "adult mouse MOp Patch-seq, ~P75",
  "_source_cluster": "cluster_04_intrinsic_electrophysiology",
  "replication_status": "replicated",
  "_source_cluster_index": 11,
  "claim_source_sentence": "For example, electrophysiological properties of the t-types within the Vip subclass varied continuously across the transcriptomic landscape; the membrane time constant, for instance, had its largest values close to the Sncg subclass and gradually decreased towards Vip Gpc3",
  "replication_evidence_dois": [
    "10.1126/science.adf6484",
    "10.1016/j.neuron.2021.08.030"
  ],
  "effect_size_source_sentence": "For example, electrophysiological properties of the t-types within the Vip subclass varied continuously across the transcriptomic landscape; the membrane time constant, for instance, had its largest values close to the Sncg subclass and gradually decreased towards Vip Gpc3"
}

[
  "paper:paper-be132b319290"
]

For example, electrophysiological properties of the t-types within the Vip subclass varied continuously across the transcriptomic landscape; the membrane time constant, for instance, had its largest values close to the Sncg subclass and gradually decreased towards Vip Gpc3

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    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
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