Version history

{
  "scope": "human neocortex layer 1; Patch-seq + snRNA-seq",
  "claim_text": "Human cortical layer 1 contains a novel rosehip interneuron with compact, bushy axonal arborizations and unusually large axonal boutons whose laminar arborization is largely confined to layer 1 — providing a contrast for evaluating the laminar specificity of mouse L1-projecting VIP cells.",
  "raw_fields": {
    "n": 76,
    "doi": "10.1038/s41593-018-0205-2",
    "claim": "Human cortical layer 1 contains a novel rosehip interneuron with compact, bushy axonal arborizations and unusually large axonal boutons whose laminar arborization is largely confined to layer 1 — providing a contrast for evaluating the laminar specificity of mouse L1-projecting VIP cells.",
    "title": null,
    "cite_key": "Boldog2018",
    "evidence": "Single-nucleus RNA-seq + biocytin reconstructions of layer-1 interneurons from human neurosurgical tissue.",
    "effect_size": "rosehip = 13% (n=10/76) of L1 interneurons sampled",
    "text_access": "fulltext",
    "study_system": "human neocortex layer 1; Patch-seq + snRNA-seq",
    "_source_cluster": "cluster_03_morphology",
    "replication_status": "replicated",
    "_source_cluster_index": 22,
    "claim_source_sentence": "The axon of RCs usually emerged from the basal part of the soma and gave rise to very compact, dense axonal trees predominantly arborizing in layer 1 with tortuous collaterals having spindle-shaped boutons with diameters not seen in other types of human layer 1 interneurons in our sample.",
    "replication_evidence_dois": [
      "10.1126/science.adf0805"
    ],
    "effect_size_source_sentence": "Light microscopic examination of these cells identified neurons with previously described morphological features, e.g. neurogliaform cells (NGFCs, n=16, 21%; Fig.2C,D ) 1 , 21 , 24 as well as a novel group of interneurons having large, rosehip-shaped axonal boutons forming very compact, bushy arborizations (rosehip cells, RCs, n=10, 13%; Fig.2A,D )."
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_04_evidence_package.json",
  "effect_size": "rosehip = 13% (n=10/76) of L1 interneurons sampled",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-04-morphology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-pm-30150662"
  ],
  "source_span": "The axon of RCs usually emerged from the basal part of the soma and gave rise to very compact, dense axonal trees predominantly arborizing in layer 1 with tortuous collaterals having spindle-shaped boutons with diameters not seen in other types of human layer 1 interneurons in our sample.",
  "study_system": "human neocortex layer 1; Patch-seq + snRNA-seq",
  "evidence_refs": [
    {
      "ref": "paper:paper-pm-30150662"
    }
  ],
  "section_title": "Morphological Diversity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Single-nucleus RNA-seq + biocytin reconstructions of layer-1 interneurons from human neurosurgical tissue.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-04-morphology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_04_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}