Human cortical layer 1 contains a novel rosehip interneuron with compact, bushy…

Human cortical layer 1 contains a novel rosehip interneuron with compact, bushy axonal arborizations and unusually large axonal boutons whose laminar arborization is largely confined to layer 1 — providing a contrast for evaluating the laminar specificity of mouse L1-projecting VIP cells.

{
  "n": 76,
  "doi": "10.1038/s41593-018-0205-2",
  "claim": "Human cortical layer 1 contains a novel rosehip interneuron with compact, bushy axonal arborizations and unusually large axonal boutons whose laminar arborization is largely confined to layer 1 — providing a contrast for evaluating the laminar specificity of mouse L1-projecting VIP cells.",
  "title": null,
  "cite_key": "Boldog2018",
  "evidence": "Single-nucleus RNA-seq + biocytin reconstructions of layer-1 interneurons from human neurosurgical tissue.",
  "effect_size": "rosehip = 13% (n=10/76) of L1 interneurons sampled",
  "text_access": "fulltext",
  "study_system": "human neocortex layer 1; Patch-seq + snRNA-seq",
  "_source_cluster": "cluster_03_morphology",
  "replication_status": "replicated",
  "_source_cluster_index": 22,
  "claim_source_sentence": "The axon of RCs usually emerged from the basal part of the soma and gave rise to very compact, dense axonal trees predominantly arborizing in layer 1 with tortuous collaterals having spindle-shaped boutons with diameters not seen in other types of human layer 1 interneurons in our sample.",
  "replication_evidence_dois": [
    "10.1126/science.adf0805"
  ],
  "effect_size_source_sentence": "Light microscopic examination of these cells identified neurons with previously described morphological features, e.g. neurogliaform cells (NGFCs, n=16, 21%; Fig.2C,D ) 1 , 21 , 24 as well as a novel group of interneurons having large, rosehip-shaped axonal boutons forming very compact, bushy arborizations (rosehip cells, RCs, n=10, 13%; Fig.2A,D )."
}

[
  "paper:paper-pm-30150662"
]

The axon of RCs usually emerged from the basal part of the soma and gave rise to very compact, dense axonal trees predominantly arborizing in layer 1 with tortuous collaterals having spindle-shaped boutons with diameters not seen in other types of human layer 1 interneurons in our sample.

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    "ref": "paper:paper-pm-30150662"
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    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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